65884-46-0|Ciadox|2-cyano-N-[(E)-(1,4-dioxidoquinoxaline-1,4-diium-2-yl)methylideneamino]acetamide|-范德生物科技公司

Ciadox

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names：
2-cyano-N-[(E)-(1,4-dioxidoquinoxaline-1,4-diium-2-yl)methylideneamino]acetamide
CAS号：
65884-46-0
MDL Number：
MF(分子式)： C12H9N5O3 MW(分子量)： 271.236
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Ciadox
英文别名	Ciadox, Cyadox
CAS号	65884-46-0
Inchi	InChI=1S/C12H9N5O3/c13-6-5-12(18)15-14-7-9-8-16(19)10-3-1-2-4-11(10)17(9)20/h1-4,7-8H,5H2,(H,15,18)/b14-7+
InchiKey	MBCZYLSVSCJJJQ-VGOFMYFVSA-N
分子式 Formula	C12H9N5O3
分子量 Molecular Weight	271.236
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ciadox(CAS:65884-46-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ciadox an antibacterial agent used in food animals, such as pigs, chickens, and carp.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Yu R, Zhang Y, Lu Q, Cui L, Wang Y, Wang X, Cheng G, Liu Z, Dai M, Yuan Z. Differentially expressed genes in response to cyadox in swine liver analyzed by DDRT-PCR. Res Vet Sci. 2018 Jun;118:72-78. doi: 10.1016/j.rvsc.2018.01.014. Epub 2018 Jan 3[1]PubMed PMID: 29421487.

[2]Liu Q, Lei Z, Zhou K, Yu H, Liu S, Sun Q, Wang X, Dai M, Yuan Z. N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. Chem Res Toxicol. 2018 Nov 19;31(11):1219-1229. doi: 10.1021/acs.chemrestox.8b00194. Epub 2018 Oct 11. PubMed PMID: 30265530.

[3] Liu Q, Lei Z, Cui L, Zhang J, Awais I, Dai M, Wang X, Yuan Z. A two-year dietary carcinogenicity study of cyadox in Sprague-Dawley rats. Regul Toxicol Pharmacol. 2017 Jul;87:9-22. doi: 10.1016/j.yrtph.2017.04.011. Epub 2017 Apr 25. PubMed PMID: 28454720.

[4] Yan L, Xie S, Chen D, Pan Y, Tao Y, Qu W, Liu Z, Yuan Z, Huang L. Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine. Sci Rep. 2017 Jun 22;7(1):4064. doi: 10.1038/s41598-017-03970-9. PubMed PMID: 28642571; PubMed Central PMCID: PMC5481453.

[5] Miao X, Xu L, Li H, Yang Z. Determination of olaquindox, carbadox and cyadox in animal feeds by ultra-performance liquid chromatography tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jul;35(7):1257-1265. doi: 10.1080/19440049.2018.1461255. Epub 2018 May 31. PubMed PMID: 29642753.

6: Huang LL, Qiu YM, Sun LL, Li J, Pan YH, Wang YL, Yuan ZH. Dietary exposure assessment of cyadox based on tissue depletion of cyadox and its major metabolites in pigs, chickens, and carp. J Vet Pharmacol Ther. 2018 Feb;41(1):125-136. doi: 10.1111/jvp.12440. Epub 2017 Dec 1. PubMed PMID: 29194660.7: Cui L, Xing D, Huang D, Li D, Lu Q, Wang X, Wang Y, Huang L, Cheng G, Hao H, Peng D, Liu Z, Dai M, Yuan Z. Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox. Biomed Pharmacother. 2018 Dec;108:1879-1893. doi: 10.1016/j.biopha.2018.09.141. Epub 2018 Oct 26. PubMed PMID: 30453449.8: Guo J, Cui L, Lu Q, Zhang Y, Liu Q, Wang X, Wang Y, Liu Z, Yuan Z, Dai M. Cyadox regulates the transcription of different genes by activation of the PI3K signaling pathway in porcine primary hepatocytes. J Cell Biochem. 2018 Nov 11. doi: 10.1002/jcb.28037. [Epub ahead of print] PubMed PMID: 30417433.9: Wang X, Zhou W, Ihsan A, Chen D, Cheng G, Hao H, Liu Z, Wang Y, Yuan Z. Assessment of thirteen-week subchronic oral toxicity of cyadox in Beagle dogs. Regul Toxicol Pharmacol. 2015 Nov;73(2):652-9. doi: 10.1016/j.yrtph.2015.09.023. Epub 2015 Sep 25. PubMed PMID: 26408151.10: Sattar A, Chen D, Jiang L, Pan Y, Tao Y, Huang L, Liu Z, Xie S, Yuan Z. Preparation, characterization and pharmacokinetics of cyadox nanosuspension. Sci Rep. 2017 May 23;7(1):2289. doi: 10.1038/s41598-017-02523-4. PubMed PMID: 28536446; PubMed Central PMCID: PMC5442105.1

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