1403-36-7|Chetomin|Chetomin, HIF signaling inhibitor|-范德生物科技公司

Chetomin

NMR下载 COA and HPLC MSDS下载
names：
Chetomin, HIF signaling inhibitor
CAS号：
1403-36-7
MDL Number：
MF(分子式)： C31H30N6O6S4 MW(分子量)： 710.857
EINECS: Reaxys Number:
Pubchem ID:10417379 Brand:BIOFOUNT

Chetomin(1403-36-7)是一种从毛壳菌属中分离的天然产物，具有抗菌和抗真菌特性。它是一种低氧诱导因子 (HIF) 信号传导的小分子抑制剂，在低纳摩尔浓度下破坏 HIF-1α 和 HIF-2α 与 p300 的结合，Chetomin 可有效减弱细胞和小鼠体内的 HIF 通路。它抑制癌细胞和异种移植物中的 HIF 依赖性信号传导、细胞生长和肿瘤生长。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Chetomin(1403-36-7);HIF信号抑制剂;HIF signaling inhibitor
英文别名	Chetomin, HIF signaling inhibitor(1403-36-7);CTM;NSC-289491;NSC 289491;NSC289491
CAS号	1403-36-7
SMILES	O=C1N(C)[C@]2(CO)C(N3[C@]1(SS2)C[C@@]4(N5C=C(C[C@]6(N(C)C7=O)SS[C@]7(CO)N(C)C6=O)C8=C5C=CC=C8)[C@]3([H])NC9=C4C=CC=C9)=O
Inchi	InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1
InchiKey	ZRZWBWPDBOVIGQ-YWZWRZHGSA-N
分子式 Formula	C31H30N6O6S4
分子量 Molecular Weight	710.857
闪点 FP	No data available
熔点 Melting point	no data available
沸点 Boiling point	no data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	白色至浅黄色固体
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Chetomin(1403-36-7)是一种从毛壳菌属中分离的天然产物，具有抗菌和抗真菌特性。它是一种低氧诱导因子 (HIF) 信号传导的小分子抑制剂，在低纳摩尔浓度下破坏 HIF-1α 和 HIF-2α 与 p300 的结合，Chetomin 可有效减弱细胞和小鼠体内的 HIF 通路。
Introduction	Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
安全声明	H315 H319 H335
安全防护	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
备注

[1]Wu Q, Li G, Deng S, Ouyang L, Li L, Liu L, Luo N, Song X, He G, Gong C, Wei Y. Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. Nanoscale. 2014 Oct 21;6(20):11940-52. doi: 10.1039/c4nr02978j. Epub 2014 Sep [1] PubMed PMID: 25175172.

[2]Yano K, Horinaka M, Yoshida T, Yasuda T, Taniguchi H, Goda AE, Wakada M, Yoshikawa S, Nakamura T, Kawauchi A, Miki T, Sakai T. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Int J Oncol. 2011 Feb;38(2):365-74. doi: 10.3892/ijo.2010.874. Epub 2010 Dec 15. PubMed PMID: 21165560.

[3] Welch TR, Williams RM. Studies on the Biosynthesis of Chetomin: Enantiospecific Synthesis of a Putative, Late-Stage Biosynthetic Intermediate. Tetrahedron. 2013 Jan 1;69(2):770-773. PubMed PMID: 24489414; PubMed Central PMCID: PMC3908826.

[4] Viziteu E, Grandmougin C, Goldschmidt H, Seckinger A, Hose D, Klein B, Moreaux J. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma. Br J Cancer. 2016 Mar 1;114(5):519-23. doi: 10.1038/bjc.2016.20. Epub 2016 Feb 11. PubMed PMID: 26867162; PubMed Central PMCID: PMC4782210.

[5] Staab A, Loeffler J, Said HM, Diehlmann D, Katzer A, Beyer M, Fleischer M, Schwab F, Baier K, Einsele H, Flentje M, Vordermark D. Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer. 2007 Nov 13;7:213. PubMed PMID: 17999771; PubMed Central PMCID: PMC2200672.

6: Jin Z, Aixi Y, Baiwen Q, Zonghuan L, Xiang H. Inhibition of hypoxia-inducible factor-1 alpha radiosensitized MG-63 human osteosarcoma cells in vitro. Tumori. 2015 Sep-Oct;101(5):578-84. doi: 10.5301/tj.5000243. Epub 2015 Aug 4. PubMed PMID: 26350185.7: Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, Vordermark D. HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer. 2010 Nov 4;10:605. doi: 10.1186/1471-2407-10-605. PubMed PMID: 21050481; PubMed Central PMCID: PMC2992520.8: Jen WC, Jones GA. Effects of chetomin on growth and acidic fermentation products of rumen bacteria. Can J Microbiol. 1983 Oct;29(10):1399-404. PubMed PMID: 6686488.9: Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW. Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol. 2015 Sep 17;22(9):1206-16. doi: 10.1016/j.chembiol.2015.07.016. Epub 2015 Aug 27. PubMed PMID: 26320861; PubMed Central PMCID: PMC4670040.10: Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, Venzon DJ, Liewehr DJ, Chau CH, Price DK, Figg WD. Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer. Mol Cancer. 2014 Apr 28;1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开