82619-04-3|Cefpodoxime sodium|sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate|-范德生物科技公司

Cefpodoxime sodium

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names：
sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS号：
82619-04-3
MDL Number：
MF(分子式)： C15H16N5NaO6S2 MW(分子量)： 449.43
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Cefpodoxime sodium
英文别名	Cefpodoxime sodium; R 3746; R-3746; R3746; R 3763; R-3763; R3763; U 76253A; U-76253A; U76253A;
CAS号	82619-04-3
Inchi	InChI=1S/C15H17N5O6S2.Na/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7;/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24);/q;+1/p-1/b19-8-;/t9-,13-;/m1./s1
InchiKey	JNMXSNGAMPXCDR-XYNKDNFRSA-M
分子式 Formula	C15H16N5NaO6S2
分子量 Molecular Weight	449.43
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cefpodoxime sodium(CAS:82619-04-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cefpodoxime sodium is a third generation cephalosporin antibiotic. It targets gram-positive and gram-negative bacteria, especially those responsible for otitis media and pharyngitis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Acharya DR, Patel DB. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cefpodoxime Proxetil and Dicloxacillin Sodium in Tablets. Indian J Pharm Sci. 2013 Jan;75(1):31-5. doi: 10.4103/0250-474X.113538. PubMed PMID: 23901158; PubMed Central PMCID: PMC3719147.

[2]Brown SA, Boucher JF, Hubbard VL, Prough MJ, Flook TF. The comparative plasma pharmacokinetics of intravenous cefpodoxime sodium and oral cefpodoxime proxetil in beagle dogs. J Vet Pharmacol Ther. 2007 Aug;30(4):320-6. PubMed PMID: 17610405.

[3] Asnani G, Jadhav K, Dhamecha D, Sankh A, Patil M. Development and validation of spectrophotometric method of cefpodoxime proxetil using hydrotropic solubilizing agents. Pharm Methods. 2012 Jul;3(2):117-20. doi: 10.4103/2229-4708.103893. PubMed PMID: 23781491; PubMed Central PMCID: PMC3658088.

[4] Mujtaba A, Kohli K. In vitro/in vivo evaluation of HPMC/alginate based extended-release matrix tablets of cefpodoxime proxetil. Int J Biol Macromol. 2016 Aug;89:434-41. doi: 10.1016/j.ijbiomac.2016.05.010. Epub 2016 May 4. PubMed PMID: 27155235.

[5] Khan F, Katara R, Ramteke S. Enhancement of bioavailability of cefpodoxime proxetil using different polymeric microparticles. AAPS PharmSciTech. 2010 Sep;11(3):1368-75. doi: 10.1208/s12249-010-9505-x. Epub 2010 Sep 4. PubMed PMID: 20821175; PubMed Central PMCID: PMC2974107.

6: Gundogdu E, Koksal C, Karasulu E. Comparison of cefpodoxime proxetil release and antimicrobial activity from tablet formulations: complexation with hydroxypropyl-β-cyclodextrin in the presence of water soluble polymer. Drug Dev Ind Pharm. 2012 Jun;38(6):689-96. doi: 10.3109/03639045.2011.621434. Epub 2011 Oct 19. PubMed PMID: 22010782.7: Hughes GS, Heald DL, Barker KB, Patel RK, Spillers CR, Watts KC, Batts DH, Euler AR. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther. 1989 Dec;46(6):674-85. PubMed PMID: 2557183.8: Sheppard M, King A, Phillips I. In vitro activity of cefpodoxime, a new oral cephalosporin, compared with that of nine other antimicrobial agents. Eur J Clin Microbiol Infect Dis. 1991 Jul;10(7):573-81. PubMed PMID: 1915400.9: Ahmed S, Abdel-Wadood HM, Mohamed NA. Highly sensitive and selective high-performance liquid chromatography method for bioequivalence study of cefpodoxime proxetil in rabbit plasma via fluorescence labeling of its active metabolite. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;93

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