1870843-22-3|CCG-224406|4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide|-范德生物科技公司

CCG-224406

NMR下载 COA and HPLC MSDS下载
names：
4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS号：
1870843-22-3
MDL Number：
MF(分子式)： C29H27FN6O5 MW(分子量)： 558.5704
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	CCG-224406
英文别名	CCG-224406; CCG 224406; CCG224406.
CAS号	1870843-22-3
Inchi	InChI=1S/C29H27FN6O5/c1-15-25(28(38)34-18-8-10-22-17(11-18)13-32-36-22)26(35-29(39)33-15)16-7-9-21(30)19(12-16)27(37)31-14-20-23(40-2)5-4-6-24(20)41-3/h4-13,26H,14H2,1-3H3,(H,31,37)(H,32,36)(H,34,38)(H2,33,35,39)
InchiKey	KQJWWWZXJNOLQF-UHFFFAOYSA-N
分子式 Formula	C29H27FN6O5
分子量 Molecular Weight	558.5704
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CCG-224406(CAS:1870843-22-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CCG-22440 is a Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitor. CCG-224406 had an IC50 for GRK2 of 130 nM, greater than 700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1. G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure.
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Waldschmidt HV, Homan KT, Cruz-Rodriguez O, Cato MC, Waninger-Saroni J,Larimore KM, Cannavo A, Song J, Cheung JY, Kirchhoff PD, Koch WJ, Tesmer JJ,Larsen SD. Structure-Based Design, Synthesis and Biological Evaluation of HighlySelective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem.2016 Apr 6. [Epub ahead of print] PubMed PMID: 27050625.