159138-81-5|Cariporide Mesylate|N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide Mesylate|-范德生物科技公司

Cariporide Mesylate

NMR下载 COA and HPLC MSDS下载
names：
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide Mesylate
CAS号：
159138-81-5
MDL Number：
MF(分子式)： C13H21N3O6S2 MW(分子量)： 379.44
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Cariporide Mesylate
英文别名	Cariporide Mesylate; Cariporide Mesylate salt; HOE642; HOE-642; HOE 642;
CAS号	159138-81-5
Inchi	InChI=1S/C12H17N3O3S.CH4O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18;1-5(2,3)4/h4-7H,1-3H3,(H4,13,14,15,16);1H3,(H,2,3,4)
InchiKey	FNDLQABGYJQJPH-UHFFFAOYSA-N
分子式 Formula	C13H21N3O6S2
分子量 Molecular Weight	379.44
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cariporide Mesylate(CAS:159138-81-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cariporide Mesylate is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Mihaila RG. A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):519-26. doi: 10.5507/bp.2015.060. Epub 2015 Nov 27. Review. PubMed PMID: 26725705.

[2]Ma D, Fang Q, Wang P, Gao R, Wu W, Lu T, Cao L, Hu X, Wang J. Induction of heme oxygenase-1 by Na+-H+ exchanger 1 protein plays a crucial role in imatinib-resistant chronic myeloid leukemia cells. J Biol Chem. 2015 May 15;290(20):12558-71. doi: 10.1074/jbc.M114.626960. Epub 2015 Mar 23. PubMed PMID: 25802333; PubMed Central PMCID: PMC4432277.

[3] Hu RH, Jin WN, Chang GQ, Lin YN, Wang J, Ru YX, Li QH, Pang TX. [Increasing sensitivity of leukemia cells to imatinib by inhibiting NHE1 and p38MAPK signaling pathway]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Dec;20(6):1341-5. Chinese. PubMed PMID: 23257429.

[4] Jin W, Li Q, Lin Y, Lu Y, Li H, Wang L, Hu R, Ma L, Wang J, Pang T. Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+ exchanger. Cancer Lett. 2011 Sep 1;308(1):81-90. doi: 10.1016/j.canlet.2011.04.016. Epub 2011 May 14. PubMed PMID: 21576001.

[5] Stanbouly S, Kirshenbaum LA, Jones DL, Karmazyn M. Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways. J Pharmacol Exp Ther. 2008 Oct;327(1):105-13. doi: 10.1124/jpet.108.140228. Epub 2008 Jul 23. PubMed PMID: 18650245.

6: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):387-408. PubMed PMID: 12851663.7: Maczewski M, Beresewicz A. Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart. Eur J Pharmacol. 2003 Feb 14;461(2-3):139-47. PubMed PMID: 12586209.8: Touret N, Poujeol P, Counillon L. Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site. Biochemistry. 2001 Apr 24;40(16):5095-101. PubMed PMID: 11305927.9: Gumina RJ, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ. Inhibition of the Na(+)/H(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation. 1999 Dec 21-28;100(25):2519-26; discussion 2469-72. PubMed PMID: 10604890.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开