4952-56-1|Caprospinol|(4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1'4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl hexanoate|-范德生物科技公司

Caprospinol

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names：
(4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1'4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl hexanoate
CAS号：
4952-56-1
MDL Number：
MF(分子式)： C33H52O4 MW(分子量)： 512.775
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Caprospinol
英文别名	Caprospinol; SP-233; SP 233; SP233
CAS号	4952-56-1
Inchi	InChI=1S/C33H52O4/c1-6-7-8-9-29(34)36-24-13-15-31(4)23(18-24)10-11-25-26(31)14-16-32(5)27(25)19-28-30(32)22(3)33(37-28)17-12-21(2)20-35-33/h10,21-22,24-28,30H,6-9,11-20H2,1-5H3/t21-,22+,24+,25-,26+,27+,28+,30+,31+,32+,33-/m1/s1
InchiKey	VMOZFSWFUBLCNN-AAPULDEBSA-N
分子式 Formula	C33H52O4
分子量 Molecular Weight	512.775
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Caprospinol(CAS:4952-56-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Caprospinol, also known as SP-233, is a β-Amyloid (Aβ) protein neurotoxicity inhibitor potentially for the treatment of Alzheimer's disease. Caprospinol crosses the blood-brain barrier, accumulates in the brain, and restores cognitive impairment in a pharmacological rat model of AD. Caprospinol is stable, does not bind to known steroid receptors, is devoid of mutagenic and genotoxic properties, and is devoid of acute toxicity in rodents.
Application1
Application2
Application3

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危险性	Warning
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备注

[1]Papadopoulos V, Lecanu L. Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. J Neuroendocrinol. 2012 Jan;24(1):93-10[1]doi: 10.1111/j.1365-2826.2011.02167.x. Review. PubMed PMID: 21623958.

[2]Lecanu L, Rammouz G, McCourty A, Sidahmed EK, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010 Jan 20;165(2):427-35. doi: 10.1016/j.neuroscience.2009.10.033. PubMed PMID: 19850110.

[3] Lecanu L, Tillement L, Rammouz G, Tillement JP, Greeson J, Papadopoulos V. Caprospinol: moving from a neuroactive steroid to a neurotropic drug. Expert Opin Investig Drugs. 2009 Mar;18(3):265-76. doi: 10.1517/13543780902762827 . Review. PubMed PMID: 19243278.

[4] Tillement L, Lecanu L, Yao W, Greeson J, Papadopoulos V. The spirostenol (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate blocks mitochondrial uptake of Abeta in neuronal cells and prevents Abeta-induced impairment of mitochondrial function. Steroids. 2006 Aug;71(8):725-35. PubMed PMID: 16787656.

[5] Chojnacki JE, Liu K, Saathoff JM, Zhang S. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease. Bioorg Med Chem. 2015 Nov 15;23(22):7324-31. doi: 10.1016/j.bmc.2015.10.032. PubMed PMID: 26526742; PubMed Central PMCID: PMC4641451.

6: Tillement L, Lecanu L, Papadopoulos V. Further evidence on mitochondrial targeting of β-amyloid and specificity of β-amyloid-induced mitotoxicity in neurons. Neurodegener Dis. 2011;8(5):331-44. doi: 10.1159/000323264. PubMed PMID: 21311166.

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