1374325-56-0|C3001a|(1S,3R)-3-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)carbamoyl)cyclopentane-1-carboxylic acid|-范德生物科技公司

C3001a

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names：
(1S,3R)-3-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)carbamoyl)cyclopentane-1-carboxylic acid
CAS号：
1374325-56-0
MDL Number：
MF(分子式)： C21H20N2O3S MW(分子量)： 380.462
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	C3001a
英文别名	C3001a; C-3001a; C 3001a;
CAS号	1374325-56-0
SMILES	O=C([C@@H]1C[C@H](C(NC2=CC=C(C3=NC4=CC=C(C)C=C4S3)C=C2)=O)CC1)O
Inchi	InChI=1S/C21H20N2O3S/c1-12-2-9-17-18(10-12)27-20(23-17)13-5-7-16(8-6-13)22-19(24)14-3-4-15(11-14)21(25)26/h2,5-10,14-15H,3-4,11H2,1H3,(H,22,24)(H,25,26)/t14-,15+/m1/s1
InchiKey	OUAZWUKQRHZQNC-CABCVRRESA-N
分子式 Formula	C21H20N2O3S
分子量 Molecular Weight	380.462
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	C3001a(CAS:1374325-56-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could advance the rational design of peripherally acting analgesics targeting K2P channels without opioid-like adverse effects.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
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TREK Channel Family Activator with a Well-Defined Structure–Activation Relationship for Pain and Neurogenic InflammationYunguang QiuLu HuangJie FuChenxia HanJing FangPing LiaoZhuo ChenYiqing MoPeihua SunDaqing LiaoLinghui YangJing WangQiansen ZhangJin LiuFeng LiuTingting LiuWei HuangHuaiyu Yang*Ruotian Jiang*Journal of Medicinal Chemistry, Articles ASAP (Article)Publication Date (Web):March 12, 2020