88331-14-0|BW 443C|(S)-1-((S)-2-(2-((R)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-5-guanidinopentanamido)acetamido)-3-(4-nitrophenyl)propanoyl)pyrrolidine-2-carboxamide diacetate|-范德生物科技公司

BW 443C

NMR下载 COA and HPLC MSDS下载
names：
(S)-1-((S)-2-(2-((R)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-5-guanidinopentanamido)acetamido)-3-(4-nitrophenyl)propanoyl)pyrrolidine-2-carboxamide diacetate
CAS号：
88331-14-0
MDL Number：
MF(分子式)： C35H50N10O12 MW(分子量)： 802.84
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	BW 443C
英文别名	BW 443C; BW-443C; BW443C; Tyr-arg-gly-(4-nitro-phe)-pro-NH2;
CAS号	88331-14-0
Inchi	InChI=1S/C31H42N10O8.2C2H4O2/c32-22(15-18-7-11-21(42)12-8-18)28(45)39-23(3-1-13-36-31(34)35)29(46)37-17-26(43)38-24(16-19-5-9-20(10-6-19)41(48)49)30(47)40-14-2-4-25(40)27(33)44;21-2(3)4/h5-12,22-25,42H,1-4,13-17,32H2,(H2,33,44)(H,37,46)(H,38,43)(H,39,45)(H4,34,35,36);21H3,(H,3,4)/t22-,23+,24-,25-;;/m0../s1
InchiKey	IDHPVZFSVGWIIP-WMEHTASQSA-N
分子式 Formula	C35H50N10O12
分子量 Molecular Weight	802.84
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	BW 443C(CAS:88331-14-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	BW 443C is a selective mu-opioid receptor agonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Belvisi MG, Stretton CD, Verleden GM, Ledingham SJ, Yacoub MH, Barnes PJ. Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100. PubMed PMID: 1314798.

[2]Adcock JJ. Peripheral opioid receptors and the cough reflex. Respir Med. 1991 Jan;85 Suppl A:43-6. Review. PubMed PMID: 1852031.

[3] Yeadon M, Wilkinson D, Darley-Usmar V, O'Leary VJ, Payne AN. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol. 1992;5(1):39-50. PubMed PMID: 1375522.

[4] Calatayud S, Quintana E, Esplugues J, Barrachina MD. Role of central oxytocin in the inhibition by endotoxin of distension-stimulated gastric acid secretion. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):676-82. PubMed PMID: 10619185.

[5] Bolser DC, DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA. Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br J Pharmacol. 1994 Dec;113(4):1344-8. PubMed PMID: 7889290; PubMed Central PMCID: PMC1510532.

6: Adcock JJ, Schneider C, Smith TW. Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol. 1988 Jan;93(1):93-100. PubMed PMID: 3349236; PubMed Central PMCID: PMC1853787.7: Posner J, Dean K, Jeal S, Moody SG, Peck AW, Rutter G, Telekes A. A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe (4NO2).Pro.NH2 (BW443C)] in healthy volunteers. Eur J Clin Pharmacol. 1988;34(1):67-71. PubMed PMID: 3360050.8: Esplugues JV, Barrachina MD, Esplugues J. Modulation by peripheral opioids of basal and distension-stimulated gastric acid secretion in the rat. Br J Pharmacol. 1992 May;106(1):33-8. PubMed PMID: 1504729; PubMed Central PMCID: PMC1907452.9: Follenfant RL, Hardy GW, Lowe LA, Schneider C, Smith TW. Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions. Br J Pharmacol. 1988 Jan;93(1):85-92. PubMed PMID: 3349235; PubMed Central PMCID: PMC1853761.10: Shankley CE, Anderson CW, Adcock JJ. Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig. Agents Actions. 1992 May;36(1-2):22-8. PubMed PMID: 1414685.1

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