123123-32-0|Bullatacin|(S)-3-((2R,13R)-2,13-dihydroxy-13-((2R,2'R,5S,5'R)-5'-((S)-1-hydroxyundecyl)octahydro-[2,2'-bifuran]-5-yl)tridecyl)-5-methylfuran-2(5H)-one|-范德生物科技公司

Bullatacin

NMR下载 COA and HPLC MSDS下载
names：
(S)-3-((2R,13R)-2,13-dihydroxy-13-((2R,2'R,5S,5'R)-5'-((S)-1-hydroxyundecyl)octahydro-[2,2'-bifuran]-5-yl)tridecyl)-5-methylfuran-2(5H)-one
CAS号：
123123-32-0
MDL Number：
MF(分子式)： C37H66O7 MW(分子量)： 622.92
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Bullatacin
英文别名	Bullatacin; LI 12105; LI-12105; LI12105 Rolliniastatin 2; Squamocin G; Annonareticin; ( )-Bullatacin;
CAS号	123123-32-0
SMILES	CCCCCCCCCC[C@H](O)[C@@H](CC1)O[C@H]1[C@H](O2)CC[C@H]2[C@H](O)CCCCCCCCCC[C@@H](O)CC3=C[C@H](C)OC3=O
Inchi	InChI=1S/C37H66O7/c1-3-4-5-6-7-11-14-17-20-31(39)33-22-24-35(43-33)36-25-23-34(44-36)32(40)21-18-15-12-9-8-10-13-16-19-30(38)27-29-26-28(2)42-37(29)41/h26,28,30-36,38-40H,3-25,27H2,1-2H3/t28-,30+,31-,32+,33+,34-,35+,36+/m0/s1
InchiKey	MBABCNBNDNGODA-BAVRERFOSA-N
分子式 Formula	C37H66O7
分子量 Molecular Weight	622.92
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bullatacin(CAS:123123-32-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone found in some fruits from Annonaceae family. It is a member of the class of compounds known as acetogenins.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chen Y, Chen JW, Liu SJ, Xu CL, Xu HQ, Cai BC, Li X, Ju WZ. Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 15;897:94-7. doi: 10.1016/j.jchromb.2012.03.044. Epub 2012 Apr 1[1]PubMed PMID: 22534655.

[2]Shi JF, Wu P, Jiang ZH, Wei XY. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. Eur J Med Chem. 2014 Jan;71:219-28. doi: 10.1016/j.ejmech.2013.11.012. Epub 2013 Nov 15. PubMed PMID: 24308999.

[3] Chih HW, Chiu HF, Tang KS, Chang FR, Wu YC. Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. Life Sci. 2001 Aug 3;69(11):1321-31. PubMed PMID: 11521756.

[4] Morré DJ, de Cabo R, Farley C, Oberlies NH, McLaughlin JL. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995;56(5):343-8. PubMed PMID: 7837933.

[5] Liang YJ, Zhang X, Dai CL, Zhang JY, Yan YY, Zeng MS, Chen LM, Fu LW. Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway. J Biomed Biotechnol. 2009;2009:867123. doi: 10.1155/2009/867123. Epub 2009 Jul 21. PubMed PMID: 19639048; PubMed Central PMCID: PMC2715821.

6: Hui YH, Rupprecht JK, Liu YM, Anderson JE, Smith DL, Chang CJ, McLaughlin JL. Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata. J Nat Prod. 1989 May-Jun;52(3):463-77. PubMed PMID: 2778448.7: Chiu HF, Chih TT, Hsian YM, Tseng CH, Wu MJ, Wu YC. Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. Biochem Pharmacol. 2003 Feb 1;65(3):319-27. PubMed PMID: 12527325.8: Mangal M, Khan MI, Agarwal SM. Acetogenins as Potential Anticancer Agents. Anticancer Agents Med Chem. 2015;16(2):138-59. Review. PubMed PMID: 26118710.9: Oberlies NH, Croy VL, Harrison ML, McLaughlin JL. The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Cancer Lett. 1997 May 1;115(1):73-9. PubMed PMID: 9097981.10: Chen Y, Chen JW, Zhai JH, Wang Y, Wang SL, Li X. Antitumor activity and toxicity relationship of annonaceous acetogenins. Food Chem Toxicol. 2013 Aug;58:394-400. doi: 10.1016/j.fct.2013.05.028. Epub 2013 May 24. PubMed PMID: 23712095.1

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