3668-14-2|Bigelovin|Ambrosa-2,11(13)-dien-12-oic acid, 6alpha,8alpha-dihydroxy-4-oxo-, 12,8-lactone, acetate|-范德生物科技公司

Bigelovin

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names：
Ambrosa-2,11(13)-dien-12-oic acid, 6alpha,8alpha-dihydroxy-4-oxo-, 12,8-lactone, acetate
CAS号：
3668-14-2
MDL Number：
MF(分子式)： C17H20O5 MW(分子量)： 304.342
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK12637-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Bigelovin
英文别名	Bigelovin
CAS号	3668-14-2
Inchi	InChI=1S/C17H20O5/c1-8-7-12-14(9(2)16(20)22-12)15(21-10(3)18)17(4)11(8)5-6-13(17)19/h5-6,8,11-12,14-15H,2,7H2,1,3-4H3/t8-,11-,12+,14+,15-,17-/m0/s1
InchiKey	DCNRYQODUSSOKC-AJYLEYFFSA-N
分子式 Formula	C17H20O5
分子量 Molecular Weight	304.342
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bigelovin(CAS:3668-14-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bigelovin has been shown to cause cell cycle arrest and subsequently induce apoptosis in cancer cells. It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang Q, Zhou BN, Zhang RW, Lin YY, Lin LZ, Gil RR, Cordell GA. Cytotoxicity and NMR spectral assignments of ergolide and bigelovin. Planta Med. 1996 Apr;62(2):166-8. PubMed PMID: 8657753.

[2]Zhang H, Li L, Chen L, Hu L, Jiang H, Shen X. Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode. J Mol Biol. 2011 Mar 18;407(1):13-20. doi: 10.1016/j.jmb.2011.01.032. Epub 2011 Jan 22. PubMed PMID: 21262235.

[3] Lee HT, Yang SW, Kim KH, Seo EK, Mar W. Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res. 2002 Apr;25(2):151-3. PubMed PMID: 12009027.

[4] Zhang HH, Kuang S, Wang Y, Sun XX, Gu Y, Hu LH, Yu Q. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells. Acta Pharmacol Sin. 2015 Apr;36(4):507-16. doi: 10.1038/aps.2014.143. Epub 2015 Jan 26. PubMed PMID: 25619393; PubMed Central PMCID: PMC4387296.

[5] Yue GG, Chan BC, Kwok HF, Wong YL, Leung HW, Ji CJ, Fung KP, Leung PC, Tan NH, Lau CB. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. Eur J Med Chem. 2013 Jan;59:243-52. doi: 10.1016/j.ejmech.2012.11.029. Epub 2012 Nov 24. PubMed PMID: 23231968.

6: Liu JL, Zeng GZ, Liu XL, Liu YQ, Hu ZG, Liu Y, Tan NH, Zhou GB. Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells. Cancer Sci. 2013 Dec;104(12):1697-704. doi: 10.1111/cas.12295. Epub 2013 Nov 8. PubMed PMID: 24118350.7: Zeng GZ, Tan NH, Ji CJ, Fan JT, Huang HQ, Han HJ, Zhou GB. Apoptosis inducement of bigelovin from Inula helianthus-aquatica on human Leukemia U937 cells. Phytother Res. 2009 Jun;23(6):885-91. doi: 10.1002/ptr.2671. PubMed PMID: 19107858.8: Nam KW, Oh GT, Seo EK, Kim KH, Koo U, Lee SJ, Mar W. Nuclear factor kappaB-mediated down-regulation of adhesion molecules: possible mechanism for inhibitory activity of bigelovin against inflammatory monocytes adhesion to endothelial cells. J Ethnopharmacol. 2009 Jun 22;123(2):250-6. doi: 10.1016/j.jep.2009.03.017. Epub 2009 Mar 26. PubMed PMID: 19429369.9: Wang X, Li X, Guo Y, Qi J, Su L, Fu Y. [Simultaneous determination of three sesquiterpene lactones in Inula hupehensis by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2011 Sep;36(18):2520-4. Chinese. PubMed PMID: 22256758.10: Park EJ, Kim J. Cytotoxic sesquiterpene lactones from Inula britannica. Planta Med. 1998 Dec;64(8):752-4. PubMed PMID: 9933993.1

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