142023-57-2|BIBS-222|2-((4-((2-butyl-6-(3-methyl-1-pentylureido)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)carbamoyl)-3,6-dichlorobenzoic acid|-范德生物科技公司

BIBS-222

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names：
2-((4-((2-butyl-6-(3-methyl-1-pentylureido)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)carbamoyl)-3,6-dichlorobenzoic acid
CAS号：
142023-57-2
MDL Number：
MF(分子式)： C33H37Cl2N5O4 MW(分子量)： 638.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	BIBS-222
英文别名	BIBS-222; BIBS 222; BIBS222;
CAS号	142023-57-2
Inchi	InChI=1S/C33H37Cl2N5O4/c1-4-6-8-18-39(33(44)36-3)23-14-17-26-27(19-23)40(28(38-26)9-7-5-2)20-21-10-12-22(13-11-21)37-31(41)29-24(34)15-16-25(35)30(29)32(42)43/h10-17,19H,4-9,18,20H2,1-3H3,(H,36,44)(H,37,41)(H,42,43)
InchiKey	ZHWGRXBJGUEATA-UHFFFAOYSA-N
分子式 Formula	C33H37Cl2N5O4
分子量 Molecular Weight	638.6
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	BIBS-222(CAS:142023-57-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	BIBS-222 is a novel nonpeptide angiotensin II (Ang II) receptor antagonist. BIBS 222 appears to be an effective antihypertensive in the model of the renal hypertensive rat.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhang J, Pfaffendorf M, van Zwieten PA. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-3[1]PubMed PMID: 7630151.

[2]Zhang J, Pfaffendorf M, van Zwieten PA. Effect of various angiotensin receptor antagonists on cardiovascular responses to angiotensin II in pithed rats. J Cardiovasc Pharmacol. 1994 Jul;24(1):108-13. PubMed PMID: 7521474.

[3] Zhang JS, Van Meel JC, Pfaffendorf M, Van Zwieten PA. Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta; the influence of receptor reserve. J Pharmacol Exp Ther. 1994 May;269(2):509-14. PubMed PMID: 8182519.

[4] Zhang JS, van Meel JC, Pfaffendorf M, van Zwieten PA. Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):538-42. PubMed PMID: 8065468.

[5] Zhang J, Van Meel JC, Van Zwieten PA. Antihypertensive activity of the novel, nonpeptide angiotensin II receptor antagonists BIBS 39 and BIBS 222 in conscious renal hypertensive rats. Pharmacology. 1993 May;46(5):241-7. PubMed PMID: 8488169.

6: van Meel JC, Entzeroth M, Hauel N, Narr B, Ries U, Wienen W. Angiotensin II receptor antagonists. Arzneimittelforschung. 1993 Feb;43(2A):242-6. Review. PubMed PMID: 8498971.7: Zhang J, Entzeroth M, Wienen W, Van Meel JC. Characterization of BIBS 39 and BIBS 22

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