78499-27-1|Bermoprofen|Dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-alpha,8-dimethyl-11-oxo-|-范德生物科技公司

Bermoprofen

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names：
Dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-alpha,8-dimethyl-11-oxo-
CAS号：
78499-27-1
MDL Number：
MF(分子式)： C18H16O4 MW(分子量)： 296.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Bermoprofen
英文别名	Bermoprofen;
CAS号	78499-27-1
Inchi	InChI=1S/C18H16O4/c1-10-3-5-16-13(7-10)9-15(19)14-8-12(11(2)18(20)21)4-6-17(14)22-16/h3-8,11H,9H2,1-2H3,(H,20,21)
InchiKey	REHLODZXMGOGQP-UHFFFAOYSA-N
分子式 Formula	C18H16O4
分子量 Molecular Weight	296.32
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bermoprofen(CAS:78499-27-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bermoprofen is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Mori M, Nakamura Y, Shirai Y, Seto Y, Nakamura H, Makita H, Imasato Y. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80. PubMed PMID: 1800712.

[2]Ishii K, Nakamura H, Yokoyama Y, Motoyoshi S, Kadokawa T. [Mode of anti-inflammatory action of a non-steroidal anti-inflammatory drug, AD-1590]. Yakugaku Zasshi. 1988 Oct;108(10):1001-7. Japanese. PubMed PMID: 3073207.

[3] Hino K, Nakamura H, Kato S, Irie A, Nagai Y, Uno H. Nonsteroidal antiinflammatory agents. III. Synthesis of the metabolites of 10,11-dihydro-8, alpha-dimethyl-11-oxodibenz-[b,f]oxepin-2-acetic acid (bermoprofen). Chem Pharm Bull (Tokyo). 1988 Sep;36(9):3462-7. PubMed PMID: 3240540.

[4] Nakamura H, Motoyoshi S, Seto Y, Kadokawa T. [Anti-inflammatory, analgesic, antipyretic and gastrointestinal ulcerogenic activities of metabolites of bermoprofen (AD-1590), a non-steroidal anti-inflammatory agent]. Yakugaku Zasshi. 1988 Aug;108(8):788-93. Japanese. PubMed PMID: 3266759.

[5] Nakamura H, Motoyoshi S, Ishii K, Kadokawa T. [Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats]. Nihon Yakurigaku Zasshi. 1988 Jul;92(1):29-38. Japanese. PubMed PMID: 3265405.

6: Nakamura H, Seto Y, Motoyoshi S, Yokoyama Y, Kadokawa T. [A correlation between the species differences in anti-inflammatory activity of AD-1590, a non-steroidal anti-inflammatory drug, and its plasma level]. Nihon Yakurigaku Zasshi. 1988 Jun;91(6):393-9. Japanese. PubMed PMID: 3138169.7: Takahashi T, Mori M, Uezono Y, Makita H, Nakanishi Y, Imasato Y. Suitable size of preparations to evaluate the bioavailability of enteric-coated preparations by the use of gastric-acidity-controlled rabbits. Chem Pharm Bull (Tokyo). 1986 Nov;34(11):4738-43. PubMed PMID: 3829190.8: Takahashi T, Kagami I, Kitamura K, Nakanishi Y, Imasato Y. Stabilization of AD-1590, a non-steroidal antiinflammatory agent, in suppository bases by beta-cyclodextrin complexation. Chem Pharm Bull (Tokyo). 1986 Apr;34(4):1770-4. PubMed PMID: 3487392.9: Yokoyama Y, Nakamura H. Effect of AD-1590, a non-steroidal anti-inflammatory agent with a potent antipyretic activity, on in vitro prostaglandin generation in rabbit brain. J Pharmacobiodyn. 1986 Apr;9(4):417-20. PubMed PMID: 3090227.10: Takahashi T, Mori M, Uezono Y, Makita H, Nakanishi Y, Imasato Y. Influence of pharmaceutical properties on gastric lesions induced in rats by AD-1590, a non-steroidal anti-inflammatory drug. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):308-14. PubMed PMID: 3486048.1

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