60189-62-0|Benzoadenosine|(2R,3R,4S,5R)-2-(8-amino-3H-imidazo[4,5-g]quinazolin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol|-范德生物科技公司

Benzoadenosine

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names：
(2R,3R,4S,5R)-2-(8-amino-3H-imidazo[4,5-g]quinazolin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS号：
60189-62-0
MDL Number：
MF(分子式)： C14H15N5O4 MW(分子量)： 317.3
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Benzoadenosine
英文别名	Benzoadenosine; NSC 287022; NSC-287022; NSC287022; Lin-benzoadenosine;
CAS号	60189-62-0
Inchi	InChI=1S/C14H15N5O4/c15-13-6-1-8-9(2-7(6)16-4-17-13)19(5-18-8)14-12(22)11(21)10(3-20)23-14/h1-2,4-5,10-12,14,20-22H,3H2,(H2,15,16,17)/t10-,11-,12-,14-/m1/s1
InchiKey	SPJSEZDBZALDCW-HKUMRIAESA-N
分子式 Formula	C14H15N5O4
分子量 Molecular Weight	317.3
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Benzoadenosine(CAS:60189-62-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Benzoadenosine inhibits kinase activity slightly less than does adenosine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lessor RA, Gibson KJ, Leonard NJ. Synthesis and biochemical evaluation of 2'-deoxy-lin-benzoadenosine phosphates. Biochemistry. 1984 Aug 14;23(17):3868-73. PubMed PMID: 6487584.

[2]Schmidt MJ, Truex LL, Leonard NJ, Scopes DI, Barrio JR. Effect of lin-benzoadenosine and lin-benzoadenosine 3':5'-monophosphate on cyclic AMP-dependent protein kinase activity in vitro. J Cyclic Nucleotide Res. 1978 Jun;4(3):201-7. PubMed PMID: 214462.

[3] Kauffman RF, Lardy HA, Barrio JR, Bario MC, Leonard NJ. Dimensional probes of the enzyme binding sites of adenine nucleotides. Interaction of lin-benzoadenosine 5'-di- and triphosphate with mitochondrial ATP synthetase, purified ATPase, and the adenine nucleotide carrier. Biochemistry. 1978 Sep 5;17(18):3686-92. PubMed PMID: 212101.

[4] Leonard NJ, Sprecker MA, Morrice AG. Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin-benzoadenosine and enzymatic evaluation of derivatives of the benzopurines. J Am Chem Soc. 1976 Jun 23;98(13):3987-94. PubMed PMID: 819479.

[5] Bhatnagar D, Hartl FT, Roskoski R Jr, Lessor RA, Leonard NJ. Adenosine cyclic 3',5'-monophosphate dependent protein kinase: nucleotide binding to the chemically modified catalytic subunit. Biochemistry. 1984 Sep 11;23(19):4350-7. PubMed PMID: 6487604.

6: Vanderlijn P, Barrio JR, Leonard NJ. Spectroscopic sensitivity of linear-benzoadenine nucleotides to divalent metal counterions, side chain conformations, micelles, and enzymes. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4204-8. PubMed PMID: 16592561; PubMed Central PMCID: PMC336080.7: Orozco M, Canela EI, Franco R. A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase. Eur J Biochem. 1990 Feb 22;188(1):155-63. PubMed PMID: 2156693.8: Scopes DI, Barrio JR, Leonard NJ. Defined dimensional changes in enzyme cofactors: fluorescent "stretched-out" analogs of adenine nucleotides. Science. 1977 Jan 21;195(4275):296-8. PubMed PMID: 188137.9: Liu H, Lynch SR, Kool ET. Solution structure of xDNA: a paired genetic helix with increased diameter. J Am Chem Soc. 2004 Jun 9;126(22):6900-5. PubMed PMID: 15174859.10: Leonard NJ, Cruickshank KA, Groziak MP, Clauson GL, Devadas B. Relatives of Watson-Crick DNA, RNA cross sections. Ann N Y Acad Sci. 1986;471:255-65. PubMed PMID: 2425693.1

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