138540-32-6|Atevirdine mesylate|Piperazine, 1-(3-(ethylamino)-2-pyridinyl)-4-((5-methoxy-1H-indol-2-yl)carbonyl)-, monomethanesulfonate|-范德生物科技公司

Atevirdine mesylate

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names：
Piperazine, 1-(3-(ethylamino)-2-pyridinyl)-4-((5-methoxy-1H-indol-2-yl)carbonyl)-, monomethanesulfonate
CAS号：
138540-32-6
MDL Number：
MF(分子式)： C22H29N5O5S MW(分子量)： 475.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Atevirdine mesylate
英文别名	Atevirdine mesylate
CAS号	138540-32-6
Inchi	InChI=1S/C21H25N5O2.CH4O3S/c1-3-22-18-5-4-8-23-20(18)25-9-11-26(12-10-25)21(27)19-14-15-13-16(28-2)6-7-17(15)24-19;1-5(2,3)4/h4-8,13-14,22,24H,3,9-12H2,1-2H3;1H3,(H,2,3,4)
InchiKey	HKPKBPALSLUFFM-UHFFFAOYSA-N
分子式 Formula	C22H29N5O5S
分子量 Molecular Weight	475.56
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Atevirdine mesylate(CAS:138540-32-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Atevirdine mesylate is an Antiviral drug.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dawood KM. Benzofuran derivatives: a patent review. Expert Opin Ther Pat. 2013 Sep;23(9):1133-56. doi: 10.1517/13543776.2013.801455. Epub 2013 May 17. Review. PubMed PMID: 23683135.

[2]Galal SA, Abd El-All AS, Hegab KH, Magd-El-Din AA, Youssef NS, El-Diwani HI. Novel antiviral benzofuran-transition metal complexes. Eur J Med Chem. 2010 Jul;45(7):3035-46. doi: 10.1016/j.ejmech.2010.03.034. Epub 2010 Mar 27. PubMed PMID: 20398971.

[3] Galal SA, Abd El-All AS, Abdallah MM, El-Diwani HI. Synthesis of potent antitumor and antiviral benzofuran derivatives. Bioorg Med Chem Lett. 2009 May 1;19(9):2420-8. doi: 10.1016/j.bmcl.2009.03.069. Epub 2009 Mar 21. PubMed PMID: 19345581.

[4] Morse GD, Reichman RC, Fischl MA, Para M, Leedom J, Powderly W, Demeter LM, Resnick L, Bassiakos Y, Timpone J, Cox S, Batts D. Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG 187 and 199 study teams. Antiviral Res. 2000 Jan;45(1):47-58. PubMed PMID: 10774589.

[5] Demeter LM, Meehan PM, Morse G, Fischl MA, Para M, Powderly W, Leedom J, Holden-Wiltse J, Greisberger C, Wood K, Timpone J Jr, Wathen LK, Nevin T, Resnick L, Batts DH, Reichman RC. Phase I study of atevirdine mesylate (U-87201E) monotherapy in HIV-1-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):135-44. PubMed PMID: 9768622.

6: Chang M, Sood VK, Wilson GJ, Kloosterman DA, Sanders PE, Schuette MR, Judy RW, Voorman RL, Maio SM, Slatter JG. Absorption, distribution, metabolism, and excretion of atevirdine in the rat. Drug Metab Dispos. 1998 Oct;26(10):1008-18. PubMed PMID: 9763407.7: Szeto ER, Freund J, Brew BJ, Loder A, Griffiths MR. Cerebral perfusion scanning in treating AIDS dementia: a pilot study. J Nucl Med. 1998 Feb;39(2):298-302. PubMed PMID: 9476939.8: Been-Tiktak AM, de Haas CJ, de Graaf L, Boucher CA, Verhoef J, Borleffs JC, Nottet HS, Schuurman R. In-vitro selection of HIV-1 variants resistant to non-nucleoside reverse transcriptase inhibitors in monocyte-derived macrophages. J Antimicrob Chemother. 1997 Dec;40(6):847-53. PubMed PMID: 9462437.9: Howard GM, Schwende FJ. Sensitive reversed-phase high-performance liquid chromatographic method for the determination of atevirdine and its N-desethyl metabolite in human saliva or cerebrospinal fluid using solid-phase extraction. J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):431-6. PubMed PMID: 9210449.10: Genin MJ, Poel TJ, Yagi Y, Biles C, Althaus I, Keiser BJ, Kopta LA, Friis JM, Reusser F, Adams WJ, Olmsted RA, Voorman RL, Thomas RC, Romero DL. Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J Med Chem. 1996 Dec 20;39(26):5267-75. PubMed PMID: 8978855.1

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