55779-06-1|Astromicin|4-Amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol|-范德生物科技公司

Astromicin

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names：
4-Amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol
CAS号：
55779-06-1
MDL Number：
MF(分子式)： C17H35N5O6 MW(分子量)： 405.496
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Astromicin
英文别名	Astromicin; KW-1070; KW 1070; KW1070; XK 70-1; XK-70-1; XK70-1.
CAS号	55779-06-1
Inchi	InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
InchiKey	BIDUPMYXGFNAEJ-APGVDKLISA-N
分子式 Formula	C17H35N5O6
分子量 Molecular Weight	405.496
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Astromicin(CAS:55779-06-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Astromicin is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Huong NL, Hoang NH, Hong SY, Sohng JK, Yoon YJ, Park JW. Characterization of fortimicin aminoglycoside profiles produced from Micromonospora olivasterospora DSM 43868 by high-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry. Anal Bioanal Chem. 2016 Feb;408(6):1667-78. doi: 10.1007/s00216-015-9281-2. Epub 2016 Jan 1[1]PubMed PMID: 26753981.

[2]Geng X, Chen X, Yang X, Guo J, Zhai G, Li X. [Cloning and sequence characterization of replication region in plasmid pJTU112 from Micoromonospora sp. 40027]. Wei Sheng Wu Xue Bao. 2013 Jun 4;53(6):623-7. Chinese. PubMed PMID: 24028065.

[3] Kim C, Villegas-Estrada A, Hesek D, Mobashery S. Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. Biochemistry. 2007 May 1;46(17):5270-82. Epub 2007 Apr 7. PubMed PMID: 17417880.

[4] Li X, Zhou X, Deng Z. Vector systems allowing efficient autonomous or integrative gene cloning in Micromonospora sp. strain 40027. Appl Environ Microbiol. 2003 Jun;69(6):3144-51. PubMed PMID: 12788709; PubMed Central PMCID: PMC161521.

[5] Boehr DD, Jenkins SI, Wright GD. The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer. J Biol Chem. 2003 Apr 11;278(15):12873-80. Epub 2003 Feb 3. PubMed PMID: 12566434.

6: Liu M, Kato M, Hashimoto Y. Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology. 2001;63(3):142-6. PubMed PMID: 11598419.7: Udou T. [Functional characterization of a multiple-antibiotic resistant plasmid from clinical isolates of methicillin-resistant Staphylococcus aureus]. Kansenshogaku Zasshi. 2001 May;75(5):382-9. Japanese. PubMed PMID: 11424487.8: Hotta K, Sunada A, Ikeda Y, Kondo S. Double stage activity in aminoglycoside antibiotics. J Antibiot (Tokyo). 2000 Oct;53(10):1168-74. PubMed PMID: 11132963.9: Zhu CB, Sunada A, Ishikawa J, Ikeda Y, Kondo S, Hotta K. Role of aminoglycoside 6'-acetyltransferase in a novel multiple aminoglycoside resistance of an actinomycete strain #8: inactivation of aminoglycosides with 6'-amino group except arbekacin and neomycin. J Antibiot (Tokyo). 1999 Oct;52(10):889-94. PubMed PMID: 10604758.10: Endo K. [Neuromuscular blocking properties of arbekacin, astromicin, isepamicin and netilmicin in the rabbit]. Jpn J Antibiot. 1999 Aug;52(8):554-61. Japanese. PubMed PMID: 10587880.1

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