114622-04-7|Ascididemin|9H-quinolino[4,3,2-de][1,10]phenanthrolin-9-one|-范德生物科技公司

Ascididemin

NMR下载 COA and HPLC MSDS下载
names：
9H-quinolino[4,3,2-de][1,10]phenanthrolin-9-one
CAS号：
114622-04-7
MDL Number：
MF(分子式)： C18H9N3O MW(分子量)： 283.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Ascididemin
英文别名	Ascididemin; Leptoclinidinone; NSC 675670; NSC-675670; NSC675670; CRL 8274; CRL-8274; CRL8274.
CAS号	114622-04-7
Inchi	InChI=1S/C18H9N3O/c22-18-12-5-3-8-19-15(12)16-14-11(7-9-20-16)10-4-1-2-6-13(10)21-17(14)18/h1-9H
InchiKey	BTAIBIXHXSXUFN-UHFFFAOYSA-N
分子式 Formula	C18H9N3O
分子量 Molecular Weight	283.29
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ascididemin(CAS:114622-04-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ascididemin can be viewed as a fused phenanthroline with quinoline; from the Mediterranean ascidian Cystodytes dellechiajei.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yin H, Shan N, Wang S, Yao ZJ. Total synthesis of ascididemin-type alkaloids using alkyne building blocks. J Org Chem. 2014 Oct 17;79(20):9748-53. doi: 10.1021/jo501927e. Epub 2014 Sep 30. PubMed PMID: 25238030.

[2]Morvan D. Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin. Mar Drugs. 2013 Oct 11;11(10):3846-60. doi: 10.3390/md11103846. PubMed PMID: 24152560; PubMed Central PMCID: PMC3826138.

[3] Petersen IN, Crestey F, Kristensen JL. Total synthesis of ascididemin via anionic cascade ring closure. Chem Commun (Camb). 2012 Sep 18;48(72):9092-4. doi: 10.1039/c2cc34725c. Epub 2012 Aug 3. PubMed PMID: 22864261.

[4] Guittat L, De Cian A, Rosu F, Gabelica V, De Pauw E, Delfourne E, Mergny JL. Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro. Biochim Biophys Acta. 2005 Aug 5;1724(3):375-84. PubMed PMID: 15950388.

[5] Matsumoto SS, Biggs J, Copp BR, Holden JA, Barrows LR. Mechanism of ascididemin-induced cytotoxicity. Chem Res Toxicol. 2003 Feb;16(2):113-22. PubMed PMID: 12588181.

6: Dirsch VM, Kirschke SO, Estermeier M, Steffan B, Vollmar AM. Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria. Oncogene. 2004 Feb 26;23(8):1586-93. PubMed PMID: 14716300.7: Sharma V, Sharma PC, Kumar V. A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry. J Adv Res. 2015 Jan;6(1):63-71. doi: 10.1016/j.jare.2014.11.002. Epub 2014 Nov 15. Review. PubMed PMID: 25685544; PubMed Central PMCID: PMC4293674.8: Delfourne E, Darro F, Portefaix P, Galaup C, Bayssade S, Bouteillé A, Le Corre L, Bastide J, Collignon F, Lesur B, Frydman A, Kiss R. Synthesis and in vitro antitumor activity of novel ring D analogues of the marine pyridoacridine ascididemin: structure-activity relationship. J Med Chem. 2002 Aug 15;45(17):3765-71. PubMed PMID: 12166949.9: Dassonneville L, Wattez N, Baldeyrou B, Mahieu C, Lansiaux A, Banaigs B, Bonnard I, Bailly C. Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells. Biochem Pharmacol. 2000 Aug 15;60(4):527-37. PubMed PMID: 10874127.10: Delfourne E, Kiss R, Le Corre L, Dujols F, Bastide J, Collignon F, Lesur B, Frydman A, Darro F. Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine. Bioorg Med Chem. 2004 Aug 1;12(15):3987-94. PubMed PMID: 15246075.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开