151581-23-6|Apaxifylline|1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-, (S)-|-范德生物科技公司

Apaxifylline

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names：
1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-, (S)-
CAS号：
151581-23-6
MDL Number：
MF(分子式)： C16H22N4O3 MW(分子量)： 318.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Apaxifylline
英文别名	Apaxifylline
CAS号	151581-23-6
SMILES	CCCn1c2c(c(=O)n(c1=O)CCC)[nH]c(n2)[C@H]3CCC(=O)C3
Inchi	1S/C16H22N4O3/c1-3-7-19-14-12(15(22)20(8-4-2)16(19)23)17-13(18-14)10-5-6-11(21)9-10/h10H,3-9H2,1-2H3,(H,17,18)/t10-/m0/s1
InchiKey	RUHGOZFOVBMWOO-JTQLQIEISA-N
分子式 Formula	C16H22N4O3
分子量 Molecular Weight	318.38
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Apaxifylline(CAS:151581-23-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Apaxifylline is a selective Adenosine A1 antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhou Y, Tong L, Chu X, Deng F, Tang J, Tang Y, Dai Y. The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. Cell Physiol Biochem. 2017;43(2):733-742. doi: 10.1159/000481557. Epub 2017 Sep 27. PubMed PMID: 28950257.

[2]Dastjerdi MN, Rarani MZ, Valiani A, Mahmoudieh M. The effect of adenosine A1 receptor agonist and antagonist on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line. Res Pharm Sci. 2016 Jul;11(4):303-10. doi: 10.4103/1735-5362.189301. PubMed PMID: 27651810; PubMed Central PMCID: PMC5022378.

[3] Zhai W, Chen D, Shen H, Chen Z, Li H, Yu Z, Chen G. A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway. Mol Brain. 2016 Jun 14;9(1):66. doi: 10.1186/s13041-016-0247-x. PubMed PMID: 27301321; PubMed Central PMCID: PMC4908780.

[4] Dastjerdi MN, Valiani A, Mardani M, Ra MZ. Adenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7. Bratisl Lek Listy. 2016;117(4):242-6. PubMed PMID: 27075390.

[5] Searl TJ, Dynda DI, Alanee SR, El-Zawahry AM, McVary KT, Silinsky EM. A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder. J Pharmacol Exp Ther. 2016 Jan;356(1):116-22. doi: 10.1124/jpet.115.228882. Epub 2015 Nov 3. PubMed PMID: 26534943; PubMed Central PMCID: PMC4702072.

6: Kusek J, Yang Q, Witek M, Gruber CW, Nanoff C, Freissmuth M. Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept. Mol Pharmacol. 2015 Jan;87(1):39-51. doi: 10.1124/mol.114.094045. Epub 2014 Oct 29. PubMed PMID: 25354767; PubMed Central PMCID: PMC4513639.7: Nascimento FP, Macedo-Júnior SJ, Pamplona FA, Luiz-Cerutti M, Córdova MM, Constantino L, Tasca CI, Dutra RC, Calixto JB, Reid A, Sawynok J, Santos AR. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78. doi: 10.1007/s12035-014-8815-5. Epub 2014 Jul 27. PubMed PMID: 25064055.

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