93767-27-2|Antioquine|(41R,61R)-16,47,66-trimethoxy-42,62-dimethyl-41,42,43,44,61,62,63,64-octahydro-5-oxa-4(1,6),6(8,1)-diisoquinolina-1,2(1,3)-dibenzenacycloheptaphane-26,67-diol|-范德生物科技公司

Antioquine

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names：
(41R,61R)-16,47,66-trimethoxy-42,62-dimethyl-41,42,43,44,61,62,63,64-octahydro-5-oxa-4(1,6),6(8,1)-diisoquinolina-1,2(1,3)-dibenzenacycloheptaphane-26,67-diol
CAS号：
93767-27-2
MDL Number：
MF(分子式)： C37H40N2O6 MW(分子量)： 608.73
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Antioquine
英文别名	Antioquine;
CAS号	93767-27-2
Inchi	InChI=1S/C37H40N2O6/c1-38-12-10-23-18-33-32(43-4)20-25(23)28(38)16-21-6-8-30(40)26(14-21)27-15-22(7-9-31(27)42-3)17-29-35-24(11-13-39(29)2)19-34(44-5)36(41)37(35)45-33/h6-9,14-15,18-20,28-29,40-41H,10-13,16-17H2,1-5H3/t28-,29-/m1/s1
InchiKey	MCVHJNNOOCVDLO-FQLXRVMXSA-N
分子式 Formula	C37H40N2O6
分子量 Molecular Weight	608.73
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Antioquine(CAS:93767-27-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Antioquine is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Pseudoxandra sclerocarpa.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ivorra MD, Lugnier C, Catret M, Anselmi E, Cortes D, D'Ocon P. Investigations of the dual contractile/relaxant properties showed by antioquine in rat aorta. Br J Pharmacol. 1993 Jun;109(2):502-9. PubMed PMID: 8358549; PubMed Central PMCID: PMC2175685.

[2]D'Ocon MP, Candenas ML, Anselmi E, Zafra-Polo MC, Cortes D. Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity. Arch Int Pharmacodyn Ther. 1989 Jan-Feb;297:205-16. PubMed PMID: 2730236.

[3] Catret M, Ivorra MD, D'Ocón MP, Anselmi E. The 5-HT and alpha-adrenoceptor antagonist effect of four benzylisoquinoline alkaloids on rat aorta. J Pharm Pharmacol. 1998 Mar;50(3):317-22. PubMed PMID: 9600725.

[4] Mahiou V, Roblot F, Fournet A, Hocquemiller R. Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae). Phytochemistry. 2000 Aug;54(7):709-16. PubMed PMID: 10975506.

[5] Correché ER, Andujar SA, Kurdelas RR, Gómez Lechón MJ, Freile ML, Enriz RD. Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. Bioorg Med Chem. 2008 Apr 1;16(7):3641-51. doi: 10.1016/j.bmc.2008.02.015. Epub 2008 Feb 8. PubMed PMID: 18295494.

6: Schleifer KJ, Tot E. Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels. J Comput Aided Mol Des. 2000 Jul;14(5):427-33. PubMed PMID: 10896315.7: Ivorra MD, Cercós A, Zafra-Polo MC, Perez-Prieto J, Sáez J, Cortes D, D'Ocon P. Selective chiral inhibition of Ca2+ entry promoted by bisbenzyltetrahydroisoquinolines in rat uterus. Eur J Pharmacol. 1992 Aug 25;219(2):303-9. PubMed PMID: 1425956.8: Protais P, Arbaoui J, Bakkali EH, Bermejo A, Cortes D. Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. PubMed PMID: 8676127.9: Granell S, Andreu I, Martí D, Cavé A, Aragón R, Estornell E, Cortes D, Zafra-Polo MC. Bisbenzyltetrahydroisoquinolines, a new class of inhibitors of the mitochondrial respiratory chain complex I. Planta Med. 2004 Mar;70(3):266-8. PubMed PMID: 15114508.10: Martinez JL, Benites J, Gomez H, Vargas-Rueda S, Vinet R, Jaimes L, Laurido C. Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta. An Acad Bras Cienc. 2018 Apr-Jun;90(2):1459-1463. doi: 10.1590/0001-3765201820170608. PubMed PMID: 29898104.1

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