170368-04-4|Anisperimus|2-((6-guanidinohexyl)amino)-2-oxoethyl (R)-(4-((3-aminobutyl)amino)butyl)carbamate|-范德生物科技公司

Anisperimus

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names：
2-((6-guanidinohexyl)amino)-2-oxoethyl (R)-(4-((3-aminobutyl)amino)butyl)carbamate
CAS号：
170368-04-4
MDL Number：
MF(分子式)： C18H39N7O3 MW(分子量)： 401.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Anisperimus
英文别名	Anisperimus; LF 15-0195; LF-15-0195; LF15-0195; LF 150195; LF-150195; LF150195;
CAS号	170368-04-4
Inchi	InChI=1S/C18H39N7O3/c1-15(19)8-13-22-9-6-7-12-25-18(27)28-14-16(26)23-10-4-2-3-5-11-24-17(20)21/h15,22H,2-14,19H2,1H3,(H,23,26)(H,25,27)(H4,20,21,24)/t15-/m1/s1
InchiKey	PZDPVSFZTKORSP-OAHLLOKOSA-N
分子式 Formula	C18H39N7O3
分子量 Molecular Weight	401.55
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Anisperimus(CAS:170368-04-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Anisperimus is an immunosuppressive agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Duplan V, Dutartre P, Druet P, Saoudi A. The immunosuppressant LF 15-0195 prevents experimental autoimmune myasthenia gravis in Brown-Norway rats. Transplant Proc. 2002 Nov;34(7):2962-5. PubMed PMID: 12431673.

[2]Duplan V, Stennevin A, Ipinazar K, Druet P, Dutartre P, Saoudi A. Beneficial effect of the immunosuppressant LF 15-0195 on passively induced rat experimental autoimmune encephalomyelitis. Transplant Proc. 2002 Nov;34(7):2966-9. PubMed PMID: 12431674.

[3] Duplan V, Dutartre P, Druet P, Saoudi A. LF 15-0195 prevents from the development and inhibits the progression of rat experimental autoimmune myasthenia gravis. J Neuroimmunol. 2002 Aug;129(1-2):115-24. PubMed PMID: 12161027.

[4] Ducoroy P, Micheau O, Perruche S, Dubrez-Daloz L, de Fornel D, Dutartre P, Saas P, Solary E. LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Blood. 2003 Jan 1;101(1):194-201. Epub 2002 Aug 29. PubMed PMID: 12393594.

[5] Yang H, Chen G, Kanai N, Shum J, Garcia B, Huang X, Min W, Luo Y, Dutartre P, Zhong R. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Transplantation. 2003 Apr 27;75(8):1166-71. PubMed PMID: 12717197.

6: Duplan V, Dutartre P, Mars LT, Liblau RS, Druet P, Saoudi A. LF 15-0195 inhibits the development of rat central nervous system autoimmunity by inducing long-lasting tolerance in autoreactive CD4 T cells. J Immunol. 2003 Feb 15;170(4):2179-85. PubMed PMID: 12574391.7: Duplan V, Beriou G, Heslan JM, Bruand C, Dutartre P, Mars LT, Liblau RS, Cuturi MC, Saoudi A. LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells. J Immunol. 2006 Jan 15;176(2):839-47. PubMed PMID: 16393967.8: Ducoroy P, de Fornel D, Dubrez-Daloz L, Solary E, Dutartre P. Longterm protection of mice against collagen-induced arthritis after short-term LF 15-0195 treatment: modulation of B and T lymphocyte activation. J Rheumatol. 2003 May;30(5):918-25. PubMed PMID: 12734883.9: Ducoroy P, de Fornel D, Chirade F, Fontet P, Dutartre P. The immunosuppressant LF 15-0195 prevents collagen-induced arthritis with IL-10 down-regulation. Transplant Proc. 2001 May;33(3):2142-5. PubMed PMID: 11377480.10: Zhong T, Liu Y, Jiang J, Wang H, Temple CL, Sun H, Garcia B, Zhong R, Ross DC. Long-term limb allograft survival using a short course of anti-CD45RB monoclonal antibody, LF 15-0195, and rapamycin in a mouse model. Transplantation. 2007 Dec 27;84(12):1636-43. doi: 10.1097/01.tp.0000290277.23186.ad. PubMed PMID: 18165776.1

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