86047-14-5|Amphimedine|8H-Benzo(b)pyrido(4,3,2-de)(1,8)phenanthroline-8,11(10H)-dione, 10-methyl-|-范德生物科技公司

Amphimedine

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names：
8H-Benzo(b)pyrido(4,3,2-de)(1,8)phenanthroline-8,11(10H)-dione, 10-methyl-
CAS号：
86047-14-5
MDL Number：
MF(分子式)： C19H11N3O2 MW(分子量)： 313.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Amphimedine
英文别名	Amphimedine
CAS号	86047-14-5
SMILES	O=C(C1=CN2C)C3=C4C(C5=CC=CC=C5N=C4C1=CC2=O)=CC=N3
Inchi	InChI=1S/C19H11N3O2/c1-22-9-13-12(8-15(22)23)17-16-11(6-7-20-18(16)19(13)24)10-4-2-3-5-14(10)21-17/h2-9H,1H3
InchiKey	GPJKOFLDDKEODA-UHFFFAOYSA-N
分子式 Formula	C19H11N3O2
分子量 Molecular Weight	313.32
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Amphimedine(CAS:86047-14-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Amphimedine is a Pyridoacridine Marine Alkaloid.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Khalil IM, Barker D, Copp BR. Bioinspired Syntheses of the Pyridoacridine Marine Alkaloids Demethyldeoxyamphimedine, Deoxyamphimedine, and Amphimedine. J Org Chem. 2016 Jan 4;81(1):282-9. doi: 10.1021/acs.joc.5b02312. Epub 2015 Dec 17. PubMed PMID: 26642369.

[2]Sharma V, Sharma PC, Kumar V. A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry. J Adv Res. 2015 Jan;6(1):63-71. doi: 10.1016/j.jare.2014.11.002. Epub 2014 Nov 15. Review. PubMed PMID: 25685544; PubMed Central PMCID: PMC4293674.

[3] Brahic C, Darro F, Belloir M, Bastide J, Kiss R, Delfourne E. Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine. Bioorg Med Chem. 2002 Sep;10(9):2845-53. PubMed PMID: 12110304.

[4] Melzer B, Plodek A, Bracher F. Total synthesis of the marine pyridoacridine alkaloid demethyldeoxyamphimedine. J Org Chem. 2014 Aug 1;79(15):7239-42. doi: 10.1021/jo501312d. Epub 2014 Jul 18. PubMed PMID: 25081029.

[5] Wei X, Bugni TS, Harper MK, Sandoval IT, Manos EJ, Swift J, Van Wagoner RM, Jones DA, Ireland CM. Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay. Mar Drugs. 2010 Jun 2;8(6):1769-78. doi: 10.3390/md8061769. PubMed PMID: 20631869; PubMed Central PMCID: PMC2901824.

6: Marshall KM, Andjelic CD, Tasdemir D, Concepción GP, Ireland CM, Barrows LR. Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Mar Drugs. 2009 May 25;7(2):196-209. doi: 10.3390/md7020196. PubMed PMID: 19597581; PubMed Central PMCID: PMC2707043.7: Marshall KM, Barrows LR. Biological activities of pyridoacridines. Nat Prod Rep. 2004 Dec;21(6):731-51. Epub 2004 Oct 29. Review. PubMed PMID: 15565252.8: Marshall KM, Matsumoto SS, Holden JA, Concepción GP, Tasdemir D, Ireland CM, Barrows LR. The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem Pharmacol. 2003 Aug 1;66(3):447-58. PubMed PMID: 12907244.9: Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxic properties of sponge-derived bisannulated acridines. J Org Chem. 2002 Dec 27;67(26):9384-91. PubMed PMID: 12492342.

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