150785-53-8|Alemcinal|8,9-didehydro-N-demethyl-9-deoxo-4', 6, 12-trideoxy-6,9-epoxy-N-ethylerythromycin|-范德生物科技公司

Alemcinal

NMR下载 COA and HPLC MSDS下载
names：
8,9-didehydro-N-demethyl-9-deoxo-4', 6, 12-trideoxy-6,9-epoxy-N-ethylerythromycin
CAS号：
150785-53-8
MDL Number：
MF(分子式)： C38H67NO10 MW(分子量)： 697.951
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Alemcinal
英文别名	Alemcinal
CAS号	150785-53-8
SMILES	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(C[C@H](C)O2)OC)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)CC)[C@@]4(C)CC(=C(O4)[C@H](C)[C@@H](O)[C@H]1C)C
Inchi	InChI=1S/C38H67NO10/c1-14-28-23(6)30(40)24(7)32-20(3)17-38(11,49-32)34(48-36-31(41)27(39(12)15-2)16-21(4)45-36)25(8)33(26(9)35(42)46-28)47-29-19-37(10,43-13)18-22(5)44-29/h21-31,33-34,36,40-41H,14-19H2,1-13H3/t21-,22+,23+,24-,25+,26-,27+,28-,29+,30+,31-,33+,34-,36+,37+,38-/m1/s1
InchiKey	IWTSXJNGTTXMFK-KTQUSEMZSA-N
分子式 Formula	C38H67NO10
分子量 Molecular Weight	697.951
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Alemcinal(CAS:150785-53-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Alemcinal is a Gastrointestinal Agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang J, Nong L, Wei Y, Qin S, Zhou Y, Tang Y. Association of osteopontin polymorphisms with nasopharyngeal carcinoma risk. Hum Immunol. 2014 Jan;75(1):76-80. doi: 10.1016/j.humimm.2013.09.014. Epub 2013 Oct 9. PubMed PMID: 24120738.

[2]Stevens JE, Jones KL, Rayner CK, Horowitz M. Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives. Expert Opin Pharmacother. 2013 Jun;14(9):1171-86. doi: 10.1517/14656566.2013.795948. Epub 2013 May 11. Review. PubMed PMID: 23663133.

[3] Wang CH, Wang LC, Jiang X, Lan L, Liu L, Sun Y, Wang BX. [Effect of interstitial cells of Cajal on gastrointestinal motility induced by motilin receptor agonist ABT-229]. Zhonghua Er Ke Za Zhi. 2010 Apr;48(4):254-9. Chinese. PubMed PMID: 20654011.

[4] Mitselos A, Vanden Berghe P, Peeters TL, Depoortere I. Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking. Biochem Pharmacol. 2008 Mar 1;75(5):1115-28. Epub 2007 Nov 19. PubMed PMID: 18096134.

[5] Takanashi H, Yogo K, Ozaki K, Koga H, Itoh Z, Omura S. In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology. 2007;79(3):137-48. Epub 2006 Dec 20. PubMed PMID: 17183187.

6: Thielemans L, Depoortere I, Perret J, Robberecht P, Liu Y, Thijs T, Carreras C, Burgeon E, Peeters TL. Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11. PubMed PMID: 15764739.7: Camilleri M. Motilin agonists and dyspepsia: throwing out the baby with the bath water. Gut. 2002 Oct;51(4):612; author reply 612-3. PubMed PMID: 12235094; PubMed Central PMCID: PMC1773416.8: Netzer P, Schmitt B, Inauen W. Effects of ABT-229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2002 Aug;16(8):1481-90. PubMed PMID: 12182748.9: Chen CL, Orr WC, Verlinden MH, Dettmer A, Brinkhoff H, Riff D, Schwartz S, Soloway RD, Krause R, Lanza F, Mack RJ. Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2002 Apr;16(4):749-57. PubMed PMID: 11929393.10: Talley NJ, Verlinden M, Geenen DJ, Hogan RB, Riff D, McCallum RW, Mack RJ. Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial. Gut. 2001 Sep;49(3):395-401. PubMed PMID: 11511562; PubMed Central PMCID: PMC1728418.1

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