150785-53-8|Alemcinal|8,9-didehydro-N-demethyl-9-deoxo-4', 6, 12-trideoxy-6,9-epoxy-N-ethylerythromycin|-范德生物科技公司

Alemcinal

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names：
8,9-didehydro-N-demethyl-9-deoxo-4', 6, 12-trideoxy-6,9-epoxy-N-ethylerythromycin
CAS号：
150785-53-8
MDL Number：
MF(分子式)： C38H67NO10 MW(分子量)： 697.951
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Alemcinal
英文别名	Alemcinal
CAS号	150785-53-8
Inchi	InChI=1S/C38H67NO10/c1-14-28-23(6)30(40)24(7)32-20(3)17-38(11,49-32)34(48-36-31(41)27(39(12)15-2)16-21(4)45-36)25(8)33(26(9)35(42)46-28)47-29-19-37(10,43-13)18-22(5)44-29/h21-31,33-34,36,40-41H,14-19H2,1-13H3/t21-,22+,23+,24-,25+,26-,27+,28-,29+,30+,31-,33+,34-,36+,37+,38-/m1/s1
InchiKey	IWTSXJNGTTXMFK-KTQUSEMZSA-N
分子式 Formula	C38H67NO10
分子量 Molecular Weight	697.951
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Alemcinal(CAS:150785-53-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Alemcinal is a Gastrointestinal Agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Stevens JE, Jones KL, Rayner CK, Horowitz M. Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives. Expert Opin Pharmacother. 2013 Jun;14(9):1171-86. doi: 10.1517/14656566.2013.795948. Epub 2013 May 11. Review. PubMed PMID: 23663133.

[3] Wang CH, Wang LC, Jiang X, Lan L, Liu L, Sun Y, Wang BX. [Effect of interstitial cells of Cajal on gastrointestinal motility induced by motilin receptor agonist ABT-229]. Zhonghua Er Ke Za Zhi. 2010 Apr;48(4):254-9. Chinese. PubMed PMID: 20654011.

[4] Mitselos A, Vanden Berghe P, Peeters TL, Depoortere I. Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking. Biochem Pharmacol. 2008 Mar 1;75(5):1115-28. Epub 2007 Nov 19. PubMed PMID: 18096134.

[5] Takanashi H, Yogo K, Ozaki K, Koga H, Itoh Z, Omura S. In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology. 2007;79(3):137-48. Epub 2006 Dec 20. PubMed PMID: 17183187.

6: Thielemans L, Depoortere I, Perret J, Robberecht P, Liu Y, Thijs T, Carreras C, Burgeon E, Peeters TL. Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11. PubMed PMID: 15764739.7: Camilleri M. Motilin agonists and dyspepsia: throwing out the baby with the bath water. Gut. 2002 Oct;51(4):612; author reply 612-3. PubMed PMID: 12235094; PubMed Central PMCID: PMC1773416.8: Netzer P, Schmitt B, Inauen W. Effects of ABT-229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2002 Aug;16(8):1481-90. PubMed PMID: 12182748.9: Chen CL, Orr WC, Verlinden MH, Dettmer A, Brinkhoff H, Riff D, Schwartz S, Soloway RD, Krause R, Lanza F, Mack RJ. Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2002 Apr;16(4):749-57. PubMed PMID: 11929393.10: Talley NJ, Verlinden M, Geenen DJ, Hogan RB, Riff D, McCallum RW, Mack RJ. Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial. Gut. 2001 Sep;49(3):395-401. PubMed PMID: 11511562; PubMed Central PMCID: PMC1728418.1

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