59960-34-8|Alclofenac lysinate|Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-, compd. with L-lysine (11)|-范德生物科技公司

Alclofenac lysinate

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names：
Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-, compd. with L-lysine (11)
CAS号：
59960-34-8
MDL Number：
MF(分子式)： C17H25ClN2O5 MW(分子量)： 372.846
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Alclofenac lysinate
英文别名	Alclofenac lysinate
CAS号	59960-34-8
SMILES	O=C(O)CC1=CC=C(OCC=C)C(Cl)=C1.N[C@@H](CCCCN)C(O)=O
Inchi	InChI=1S/C11H11ClO3.C6H14N2O2/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14;7-4-2-1-3-5(8)6(9)10/h2-4,6H,1,5,7H2,(H,13,14);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
InchiKey	YDINFUGJNRFTDV-ZSCHJXSPSA-N
分子式 Formula	C17H25ClN2O5
分子量 Molecular Weight	372.846
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Alclofenac lysinate(CAS:59960-34-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Alclofenac is an anti-inflammatory agent used in the treatment of rheumatoid arthritis; acts also as an analgesic and an antipyretic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Knights KM, Winner LK, Elliot DJ, Bowalgaha K, Miners JO. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009 Sep;68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. PubMed PMID: 19740398; PubMed Central PMCID: PMC2766480.

[2]Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006034. Review. PubMed PMID: 17054271.

[3] Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80. PubMed PMID: 11318639.

[4] Fillet M, Bechet I, Piette V, Crommen J. Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes. Electrophoresis. 1999 Jul;20(9):1907-15. PubMed PMID: 10445335.

[5] Delbeke FT, Landuyt J, Debackere M. Disposition of human drug preparations in the horse. III. Orally administered alclofenac. J Vet Pharmacol Ther. 1994 Oct;17(5):353-8. PubMed PMID: 7853459.

6: Lee CK, Uchida T, Kitagawa K, Yagi A, Kim NS, Goto S. Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers. Biol Pharm Bull. 1993 Dec;16(12):1264-9. PubMed PMID: 7907514.7: Delbeke FT, Landuyt J, Debackere M. Determination of alclofenac in equine plasma and urine by high-performance liquid chromatography. J Chromatogr. 1993 Nov 24;621(2):209-14. PubMed PMID: 7905004.8: Uchida T, Lee CK, Sekiya N, Goto S. Enhancement effect of an ethanol/Panasate 800 binary vehicle on anti-inflammatory drug permeation across excised hairless mouse skin. Biol Pharm Bull. 1993 Feb;16(2):168-71. PubMed PMID: 8364453.9: Kamiya Y, Nakabayashi K, Suzuki M, Motohashi S, Maemura C, Kitamoto K, Nagasawa T. [A case of concurrent occurrence of acute renal failure and nephrotic syndrome induced by alclofenac]. Nihon Naika Gakkai Zasshi. 1989 Jul;78(7):958-63. Japanese. PubMed PMID: 2571652.10: de Jong EG, Kiffers J, Maes RA. The determination of non-steroidal anti-inflammatory drugs by GC-MS-MS in equine urine. J Pharm Biomed Anal. 1989;7(12):1617-22. PubMed PMID: 2490551.1

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