478132-11-5|AL-38022A|(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamin|-范德生物科技公司

AL-38022A

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names：
(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamin
CAS号：
478132-11-5
MDL Number：
MF(分子式)： C13H17N3O MW(分子量)： 231.299
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	AL-38022A
英文别名	AL-38022A; AL 38022A; AL38022A; Pubchem ID# 22496603.
CAS号	478132-11-5
Inchi	InChI=1S/C13H17N3O/c1-9(14)8-16-13-10(7-15-16)4-5-12-11(13)3-2-6-17-12/h4-5,7,9H,2-3,6,8,14H2,1H3/t9-/m0/s1
InchiKey	FJRIVFVALIEIOY-VIFPVBQESA-N
分子式 Formula	C13H17N3O
分子量 Molecular Weight	231.299
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AL-38022A(CAS:478132-11-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT2 receptor subtypes (Ki100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displayed a very low affinity for a broad array of other receptors, neurotransmitter transport sites, ion channels, and second messenger elements, making it a relatively selective agent. AL-38022A potently stimulated functional responses via native and cloned rat (EC50 range 1.9-22.5 nM) and human (EC50 range 0.5-2.2 nM) 5-HT2 receptor subtypes including [Ca2+]i mobilization and tissue contractions with apparently similar potencies and intrinsic activities and was a full agonist at all 5-HT2 receptor subtypes.
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, Young R, Li JX,Rice KC, France CP. Pharmacological properties and discriminative stimuluseffects of a novel and selective 5-HT2 receptor agonist AL-38022A[(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. PharmacolBiochem Behav. 2009 Jan;91(3):307-14. doi: 10.1016/j.pbb.2008.07.015. Epub 2008Jul 30. PubMed PMID: 18718483; PubMed Central PMCID: PMC3763814.