168836-03-1|AG1433|2-(3,4-dihydroxyphenyl)-6,7-dimethylquinoxaline|-范德生物科技公司

AG1433

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names：
2-(3,4-dihydroxyphenyl)-6,7-dimethylquinoxaline
CAS号：
168836-03-1
MDL Number：
MF(分子式)： C16H14N2O2 MW(分子量)： 266.3
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	AG1433
英文别名	AG1433; AG-1433; AG 1433; Tyrphostin AG-1433; Tyrphostin AG 1433; Tyrphostin AG1433;
CAS号	168836-03-1
SMILES	CC1=C(C)C=C2N=CC(C3=CC=C(O)C(O)=C3)=NC2=C1
Inchi	InChI=1S/C16H14N2O2/c1-9-5-12-13(6-10(9)2)18-14(8-17-12)11-3-4-15(19)16(20)7-11/h3-8,19-20H,1-2H3
InchiKey	SMKFYHOKXJUJOT-UHFFFAOYSA-N
分子式 Formula	C16H14N2O2
分子量 Molecular Weight	266.3
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AG1433(CAS:168836-03-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AG1433 is an inhibitor of tyrosine kinases. It also acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Serban F, Daianu O, Tataranu LG, Artene SA, Emami G, Georgescu AM, Alexandru O, Purcaru SO, Tache DE, Danciulescu MM, Sfredel V, Dricu A. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. doi: 10.1080/15321819.2016.1209217. Epub 2016 Jul 5. PubMed PMID: 27379831.

[2]Popescu AM, Alexandru O, Brindusa C, Purcaru SO, Tache DE, Tataranu LG, Taisescu C, Dricu A. Targeting the VEGF and PDGF signaling pathway in glioblastoma treatment. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7825-37. eCollection 2015. PubMed PMID: 26339347; PubMed Central PMCID: PMC4555675.

[3] Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. doi: 10.1242/dmm.004689. Epub 2010 Sep 27. PubMed PMID: 20876357.

[4] Akiyama N, Naruse K, Kobayashi Y, Nakamura N, Hamada Y, Nakashima E, Matsubara T, Oiso Y, Nakamura J. High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells. J Mol Cell Cardiol. 2008 Aug;45(2):326-32. doi: 10.1016/j.yjmcc.2008.04.006. Epub 2008 Apr 25. PubMed PMID: 18561944.

[5] Chen K, Albano A, Ho A, Keaney JF Jr. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J Biol Chem. 2003 Oct 10;278(41):39527-33. Epub 2003 Jul 30. PubMed PMID: 12890678.

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