1446711-81-4|AG-10|Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-|-范德生物科技公司

AG-10

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names：
Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-
CAS号：
1446711-81-4
MDL Number：
MF(分子式)： C15H17FN2O3 MW(分子量)： 292.31
EINECS:Cc1n[nH]c(C)c1CCCOc2cc(ccc2F)C(=O)O Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

AG-10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.

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中文别名	AG-10,Acoramidis, AG-10, AG10
英文别名	Acoramidis, AG-10, AG10, AG 10,Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-
CAS号	1446711-81-4
Inchi	1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
InchiKey	WBFUHHBPNXWNCC-UHFFFAOYSA-N
分子式 Formula	C15H17FN2O3
分子量 Molecular Weight	292.31
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

AG10 has been shown to stabilize Transthyretin (TTR or TBPA) --- a transport protein in serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol --- in Symptomatic Transthyretin Amyloid Cardiomyopathy. In this way, AG10 mimics a naturally occurring genetic variant, T119M, that protects from Transthyretin Amyloidosis.

产品说明	AG-10(CAS:1446711-81-4):AG-10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Introduction	AG-10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. AG10 has been shown to stabilize Transthyretin (TTR or TBPA) --- a transport protein in serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol --- in Symptomatic Transthyretin Amyloid Cardiomyopathy. In this way, AG10 mimics a naturally occurring genetic variant, T119M, that protects from Transthyretin Amyloidosis.
Application1
Application2
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Judge DP, Falk RH, Maurer MS, Shah SJ, Witteles RM, Grogan M, Selby VN, Jacoby D, Hanna M, Nativi-Nicolau J, Patel J, Rao S, Sinha U, Turtle CW, Fox JC, Heitner SB. Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy. J Am Coll Cardiol. 2019 Mar 12. pii: S0735-1097(19)33920-8. doi: 10.1016/j.jacc.2019.03.012. [Epub ahead of print] PubMed PMID: 30885685.

[2]Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, Kumar N, Fox J, Sinha U, Alhamadsheh M. Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. J Med Chem. 2018 Sep 13;61(17):7862-7876. doi: 10.1021/acs.jmedchem.8b00817. Epub 2018 Aug 22. PubMed PMID: 30133284; PubMed Central PMCID: PMC6276790.

[3] Petty JT, Sergev OO, Ganguly M, Rankine IJ, Chevrier DM, Zhang P. A Segregated, Partially Oxidized, and Compact Ag10 Cluster within an Encapsulating DNA Host. J Am Chem Soc. 2016 Mar 16;138(10):3469-77. doi: 10.1021/jacs.5b13124. Epub 2016 Mar 7. PubMed PMID: 26924556; PubMed Central PMCID: PMC6118400.

[4] Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. doi: 10.1073/pnas.1300761110. Epub 2013 May 28. PubMed PMID: 23716704; PubMed Central PMCID: PMC3683741.

[5] Avlonitis N, Chalmers S, McDougall C, Stanton-Humphreys MN, Brown CT, McCarron JG, Conway SJ. Caged AG10: new tools for spatially predefined mitochondrial uncoupling. Mol Biosyst. 2009 May;5(5):450-7. doi: 10.1039/b820415m. Epub 2009 Mar 31. PubMed PMID: 19381360.

6: Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. Epub 2003 Dec 19. PubMed PMID: 14688271.

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