79982-94-8|AFB1-N7-guanine|Cyclopenta(c)furo(3',2'4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 8-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2,3,6a,8,9,9a-hexahydro-9-hydroxy-4-methoxy-, (6aS-(6aalpha,8beta,9alpha,9aalpha))-|-范德生物科技公司

AFB1-N7-guanine

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names：
Cyclopenta(c)furo(3',2'4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 8-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2,3,6a,8,9,9a-hexahydro-9-hydroxy-4-methoxy-, (6aS-(6aalpha,8beta,9alpha,9aalpha))-
CAS号：
79982-94-8
MDL Number：
MF(分子式)： C22H17N5O8 MW(分子量)： 479.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AFB1-N7-guanine
英文别名	AFB1-N7-guanine;
CAS号	79982-94-8
Inchi	InChI=1S/C22H17N5O8/c1-32-8-4-9-12(16-11(8)6-2-3-7(28)10(6)20(31)34-16)13-15(29)19(35-21(13)33-9)27-5-24-14-17(27)25-22(23)26-18(14)30/h4-5,13,15,19,21,29H,2-3H2,1H3,(H3,23,25,26,30)/t13-,15-,19-,21+/m1/s1
InchiKey	GXTQFZWLCDHVQV-CKJDJMSUSA-N
分子式 Formula	C22H17N5O8
分子量 Molecular Weight	479.41
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AFB1-N7-guanine(CAS:79982-94-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure in epidemiological studies.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM. Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017 Nov 1;160(1):173-179. doi: 10.1093/toxsci/kfx17[1]PubMed PMID: 28973694; PubMed Central PMCID: PMC5837592.

[2]Mupunga I, Izaaks CD, Shai LJ, Katerere DR. Aflatoxin biomarkers in hair may facilitate long-term exposure studies. J Appl Toxicol. 2017 Apr;37(4):395-399. doi: 10.1002/jat.3422. Epub 2016 Dec 9. Review. PubMed PMID: 27933645.

[3] Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12. PubMed PMID: 27071940; PubMed Central PMCID: PMC4922541.

[4] Reddy L, Odhav B, Bhoola K. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biol Chem. 2006 Jan;387(1):87-93. PubMed PMID: 16497168.

[5] Nayak S, Sashidhar RB, Bhat RV. Quantification and validation of enzyme immunoassay for urinary aflatoxin B1-N7-guanine adduct for biological monitoring of aflatoxins. Analyst. 2001 Feb;126(2):179-83. PubMed PMID: 11235100.

6: Ha TG, Jang JJ, Kim SG, Kim ND. 2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats. Chem Biol Interact. 1999 Jul 1;121(2):209-22. PubMed PMID: 10418965.7: Wang JS, Groopman JD. DNA damage by mycotoxins. Mutat Res. 1999 Mar 8;424(1-2):167-81. Review. PubMed PMID: 10064859.8: de Oliveira CA, Germano PM. [Aflatoxins: current concepts on mechanisms of toxicity and their involvement in the etiology of hepatocellular carcinoma]. Rev Saude Publica. 1997 Aug;31(4):417-24. Review. Portuguese. PubMed PMID: 9595771.9: Yu MW, Lien JP, Chiu YH, Santella RM, Liaw YF, Chen CJ. Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. J Hepatol. 1997 Aug;27(2):320-30. PubMed PMID: 9288607.10: Vidyasagar T, Sujatha N, Sashidhar RB. Direct synthesis of aflatoxin B1-N7 guanine adduct: a reference standard for biological monitoring of dietary aflatoxin exposure in molecular epidemiological studies. Food Addit Contam. 1997 Jul;14(5):457-67. PubMed PMID: 9328530.1

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