114987-18-7|Adenallene|2,3-Butadien-1-ol, 4-(6-amino-9H-purin-9-yl)-, (+-)-|-范德生物科技公司

Adenallene

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names：
2,3-Butadien-1-ol, 4-(6-amino-9H-purin-9-yl)-, (+-)-
CAS号：
114987-18-7
MDL Number：
MF(分子式)： C9H9N5O MW(分子量)： 203.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Adenallene
英文别名	Adenallene;
CAS号	114987-18-7
Inchi	InChI=1S/C9H9N5O/c10-8-7-9(12-5-11-8)14(6-13-7)3-1-2-4-15/h2-3,5-6,15H,4H2,(H2,10,11,12)
InchiKey	TYQIYCWCVLIXPH-UHFFFAOYSA-N
分子式 Formula	C9H9N5O
分子量 Molecular Weight	203.21
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Adenallene(CAS:114987-18-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Adenallene Inhibits replication and cytopathic effects of HIV in vitro.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Egron D, Périgaud C, Gosselin G, Aubertin AM, Gatanaga H, Mitsuya H, Zemlicka J, Imbach JL. Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative. Bioorg Med Chem Lett. 2002 Jan 21;12(2):265-6. PubMed PMID: 11755368.

[2]Winter H, Maeda Y, Uchida H, Mitsuya H, Zemlicka J. Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity. J Med Chem. 1997 Jul 4;40(14):2191-5. PubMed PMID: 9216838.

[3] Winter H, Maeda Y, Mitsuya H, Zemlicka J. Phosphodiester amidates of allenic nucleoside analogues: anti-HIV activity and possible mechanism of action. J Med Chem. 1996 Aug 16;39(17):3300-6. PubMed PMID: 8765513.

[4] Jones BC, Silverton JV, Simons C, Megati S, Nishimura H, Maeda Y, Mitsuya H, Zemlicka J. Synthesis, absolute configuration, and enantioselectivity of antiretroviral effect of (R)-(-)- and (S)-(+)-cytallene. Lipase-catalyzed enantioselective acylations of (+/-)-N4-acylcytallenes. J Med Chem. 1995 Apr 14;38(8):1397-405. PubMed PMID: 7731024.

[5] Kessel D, Zemlicka J. Accumulation and metabolism of adenallene by murine leukemia L1210 cells. Arch Biochem Biophys. 1994 Jan;308(1):222-5. PubMed PMID: 8311456.

6: Megati S, Goren Z, Silverton JV, Orlina J, Nishimura H, Shirasaki T, Mitsuya H, Zemlicka J. (R)-(-)- and (S)-(+)-adenallene: synthesis, absolute configuration, enantioselectivity of antiretroviral effect, and enzymic deamination. J Med Chem. 1992 Oct 30;35(22):4098-104. Erratum in: J Med Chem 1993 Mar 5;36(5):634. PubMed PMID: 1304169.7: Kierdaszuk B, Bohman C, Ullman B, Eriksson S. Substrate specificity of human deoxycytidine kinase toward antiviral 2',3'-dideoxynucleoside analogs. Biochem Pharmacol. 1992 Jan 22;43(2):197-206. PubMed PMID: 1739408.8: Kochetkova MV, Tsytovich AV, Mitsner BI. A convenient approach to the synthesis of nucleic acid bases allenic derivatives, possessing anti-HIV activity. Nucleic Acids Symp Ser. 1991;(24):233. PubMed PMID: 1841305.9: Khorlin AA, Smirnov IP, Kochetkova SV, Tsilevich TL, Shchaveleva IL. [Compounds similar to acyclovir. IV. A convenient method of synthesizing adenallene]. Bioorg Khim. 1989 Apr;15(4):530-3. Russian. PubMed PMID: 2751711.10: Hayashi S, Phadtare S, Zemlicka J, Matsukura M, Mitsuya H, Broder S. Adenallene and cytallene: acyclic-nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6127-31. PubMed PMID: 3261865; PubMed Central PMCID: PMC281918.

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