1633766-73-0|ADB-PINACA|N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide|-范德生物科技公司

ADB-PINACA

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names：
N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide
CAS号：
1633766-73-0
MDL Number：
MF(分子式)： C19H28N4O2 MW(分子量)： 344.459
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ADB-PINACA
英文别名	ADB-PINACA; UNII-U1Q4F41C9U
CAS号	1633766-73-0
Inchi	InChI=1S/C19H28N4O2/c1-5-6-9-12-23-14-11-8-7-10-13(14)15(22-23)18(25)21-16(17(20)24)19(2,3)4/h7-8,10-11,16H,5-6,9,12H2,1-4H3,(H2,20,24)(H,21,25)
InchiKey	FWTARAXQGJRQKN-UHFFFAOYSA-N
分子式 Formula	C19H28N4O2
分子量 Molecular Weight	344.459
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ADB-PINACA(CAS:1633766-73-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ADB-PINACA is discontinued (DEA controlled substance). It is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.52 nM and 0.88 nM respectively. Like MDMB-FUBINACA, this compound contains an amino acid residue of tert-leucine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Armenian P, Darracq M, Gevorkyan J, Clark S, Kaye B, Brandehoff NP. Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature. Neuropharmacology. 2018 May 15;134(Pt A):82-9[1]doi: 10.1016/j.neuropharm.2017.10.017. Epub 2017 Oct 14. Review. PubMed PMID: 29037744.

[2]Longworth M, Connor M, Banister SD, Kassiou M. Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA. ACS Chem Neurosci. 2017 Aug 16;8(8):1673-1680. doi: 10.1021/acschemneuro.7b00116. Epub 2017 Jun 8. PubMed PMID: 28574245.

[3] Carlier J, Diao X, Scheidweiler KB, Huestis MA. Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry. Clin Chem. 2017 May;63(5):1008-1021. doi: 10.1373/clinchem.2016.267575. Epub 2017 Mar 16. PubMed PMID: 28302730.

[4] Hess C, Krueger L, Unger M, Madea B. Freeze-thaw stability and long-term stability of 84 synthetic cannabinoids in serum. Drug Test Anal. 2017 Oct;9(10):1506-1511. doi: 10.1002/dta.2133. Epub 2016 Dec 28. PubMed PMID: 27863089.

[5] Tournebize J, Gibaja V, Kahn JP. Acute effects of synthetic cannabinoids: Update 2015. Subst Abus. 2017 Jul-Sep;38(3):344-366. doi: 10.1080/08897077.2016.1219438. Epub 2016 Aug 11. Review. PubMed PMID: 27715709.

6: Tynon M, Homan J, Kacinko S, Ervin A, McMullin M, Logan BK. Rapid and sensitive screening and confirmation of thirty-four aminocarbonyl/carboxamide (NACA) and arylindole synthetic cannabinoid drugs in human whole blood. Drug Test Anal. 2017 Jun;9(6):924-934. doi: 10.1002/dta.2096. Epub 2016 Oct 13. PubMed PMID: 27653946.7: Drug Enforcement Administration, Department of Justice. Schedules of Controlled Substances: Placement of PB-22, 5F-PB-22, AB-FUBINACA and ADB-PINACA into Schedule I. Final rule. Fed Regist. 2016 Sep 6;81(172):61130-3. PubMed PMID: 27632803.8: Gatch MB, Forster MJ. Δ(9)-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats. Psychopharmacology (Berl). 2016 May;233(10):1901-10. doi: 10.1007/s00213-016-4237-6. Epub 2016 Feb 15. PubMed PMID: 26875756; PubMed Central PMCID: PMC4846470.9: Drug Enforcement Administration, Department of Justice. Schedules of Controlled Substances: Extension of Temporary Placement of PB-22, 5F-PB-22, AB-FUBINACA and ADB-PINACA in Schedule I of the Controlled Substances Act. Final order. Fed Regist. 2016 Feb 5;81(24):6175-7. PubMed PMID: 26859904.10: Hasegawa K, Wurita A, Minakata K, Gonmori K, Nozawa H, Yamagishi I, Watanabe K, Suzuki O. Postmortem distribution of MAB-CHMINACA in body fluids and solid tissues of a human cadaver. Forensic Toxicol. 2015;33(2):380-387. doi: 10.1007/s11419-015-0272-y. Epub 2015 Mar 10. PubMed PMID: 26257834; PubMed Central PMCID: PMC4525191.1

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