36983-69-4|Actodigin|24-Nor-5,14-chol-20(22)-en-21-oic acid, 3-(beta-D-glucopyranosyloxy)-14,23-dihydroxy-, gamma-lactone, (3beta,5beta,14beta)-|-范德生物科技公司

Actodigin

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names：
24-Nor-5,14-chol-20(22)-en-21-oic acid, 3-(beta-D-glucopyranosyloxy)-14,23-dihydroxy-, gamma-lactone, (3beta,5beta,14beta)-
CAS号：
36983-69-4
MDL Number：
MF(分子式)： C29H44O9 MW(分子量)： 536.66
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Actodigin
英文别名	NSC 53396; NSC-53396; NSC53396; Actodigin
CAS号	36983-69-4
Inchi	InChI=1S/C29H44O9/c1-27-9-5-16(37-26-24(33)23(32)22(31)21(14-30)38-26)13-15(27)3-4-20-19(27)6-10-28(2)18(7-11-29(20,28)35)17-8-12-36-25(17)34/h8,15-16,18-24,26,30-33,35H,3-7,9-14H2,1-2H3/t15-,16+,18-,19+,20-,21-,22-,23+,24-,26-,27+,28-,29+/m1/s1
InchiKey	ACLJAFRNPZVVIW-ADFGDECNSA-N
分子式 Formula	C29H44O9
分子量 Molecular Weight	536.66
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Actodigin(CAS:36983-69-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Actodiginis a Cardiotonic drug.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Ruch SR, Nishio M, Wasserstrom JA. Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload. J Pharmacol Exp Ther. 2003 Oct;307(1):419-28. Epub 2003 Sep 3. PubMed PMID: 12954807.

[2]Sagawa T, Sagawa K, Kelly JE, Tsushima RG, Wasserstrom JA. Activation of cardiac ryanodine receptors by cardiac glycosides. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1118-26. PubMed PMID: 11834511.

[3] Wasserstrom JA. Changes in intracellular Na+ during Na,K pump inhibition in sheep cardiac tissues. J Mol Cell Cardiol. 1992 Jan;24(1):1-7. PubMed PMID: 1314312.

[4] Wasserstrom JA, Farkas DE, Norell MA, Vereault DV. Effects of different cardiac steroids on intracellular sodium, inotropy and toxicity in sheep Purkinje fibers. J Pharmacol Exp Ther. 1991 Sep;258(3):918-25. PubMed PMID: 1890626.

[5] Wasserstrom JA, Farkas DE. Inotropic and toxic actions of several cardiac steroids in sheep cardiac tissues. Prog Clin Biol Res. 1988;268B:469-76. PubMed PMID: 3222261.

6: Gupta RS, Chopra A. Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. Biochem Pharmacol. 1987 Nov 15;36(22):3829-33. PubMed PMID: 2825704.7: Gupta RS, Chopra A, Stetsko DK. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol. 1986 May;127(2):197-206. PubMed PMID: 3009493.8: Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PubMed PMID: 2987235.9: Haustein KO. Therapeutic range of cardiac glycosides. Basic Res Cardiol. 1984;79 Suppl:147-53. PubMed PMID: 6331374.10: Wasserstrom JA, Schwartz DJ, Fozzard HA. Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides. Circ Res. 1983 Jun;52(6):697-705. PubMed PMID: 6305531.1

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