1088434-86-9|ACS67|5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-|-范德生物科技公司

ACS67

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names：
5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-
CAS号：
1088434-86-9
MDL Number：
MF(分子式)： C32H38O5S3 MW(分子量)： 598.83
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ACS67
英文别名	ACS67; ACS-67; ACS 67
CAS号	1088434-86-9
Inchi	InChI=1S/C32H38O5S3/c33-24(15-12-22-8-4-3-5-9-22)16-19-27-26(28(34)20-29(27)35)10-6-1-2-7-11-31(36)37-25-17-13-23(14-18-25)30-21-32(38)40-39-30/h1,3-6,8-9,13-14,17-18,21,24,26-29,33-35H,2,7,10-12,15-16,19-20H2/b6-1-/t24-,26+,27+,28-,29+/m0/s1
InchiKey	JEEWZRQQYWVJCX-WEWVERJPSA-N
分子式 Formula	C32H38O5S3
分子量 Molecular Weight	598.83
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ACS67(CAS:1088434-86-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ACS67 is an F-series prostaglandin (PG) analog for treatment of glaucoma. ACS 67 reduces intra-ocular pressure (IOP) and increases levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits. ACS67 also acts as a neuroprotectant that stimulates GSH levels.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Osborne NN, Ji D, Abdul Majid AS, Fawcett RJ, Sparatore A, Del Soldato P. ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):284-94. doi: 10.1167/iovs.09-3999. Epub 2009 Aug 26. PubMed PMID: 19710416.

[2]Salvi A, Bankhele P, Jamil J, Chitnis MK, Njie-Mbye YF, Ohia SE, Opere CA. Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits. J Ocul Pharmacol Ther. 2016 Jul-Aug;32(6):371-5. doi: 10.1089/jop.2015.0144. Epub 2016 Apr 19. PubMed PMID: 27092593; PubMed Central PMCID: PMC4960495.

[3] Salvi A, Bankhele P, Jamil JM, Kulkarni-Chitnis M, Njie-Mbye YF, Ohia SE, Opere CA. Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro. Neurochem Res. 2016 May;41(5):1020-8. doi: 10.1007/s11064-015-1784-x. Epub 2015 Dec 23. PubMed PMID: 26700431.

[4] Tang G, Zhang L, Yang G, Wu L, Wang R. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells. Diabetologia. 2013 Mar;56(3):533-41. doi: 10.1007/s00125-012-2806-8. Epub 2012 Dec 30. PubMed PMID: 23275972.

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