134044-97-6|Aciculatin|4H-1-Benzopyran-4-one, 8-(2,6-dideoxy-beta-D-ribo-hexopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-|-范德生物科技公司

Aciculatin

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names：
4H-1-Benzopyran-4-one, 8-(2,6-dideoxy-beta-D-ribo-hexopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
CAS号：
134044-97-6
MDL Number：
MF(分子式)： C22H22O8 MW(分子量)： 414.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Aciculatin
英文别名	Aciculatin;
CAS号	134044-97-6
Inchi	InChI=1S/C22H22O8/c1-10-21(27)15(26)9-18(29-10)20-17(28-2)8-14(25)19-13(24)7-16(30-22(19)20)11-3-5-12(23)6-4-11/h3-8,10,15,18,21,23,25-27H,9H2,1-2H3/t10-,15+,18-,21-/m1/s1
InchiKey	RUTGHCUXABPJTJ-DJIPSUEUSA-N
分子式 Formula	C22H22O8
分子量 Molecular Weight	414.41
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Aciculatin(CAS:134044-97-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. Aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yao CH, Tsai CH, Lee JC. Total Synthesis of the Naturally Occurring Glycosylflavone Aciculatin. J Nat Prod. 2016 Jul 22;79(7):1719-23. doi: 10.1021/acs.jnatprod.5b0105[1]Epub 2016 Jun 20. PubMed PMID: 27322193.

[2]Lai CY, Tsai AC, Chen MC, Chang LH, Sun HL, Chang YL, Chen CC, Teng CM, Pan SL. Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. PLoS One. 2012;7(8):e42192. doi: 10.1371/journal.pone.0042192. Epub 2012 Aug 13. PubMed PMID: 22912688; PubMed Central PMCID: PMC3418269.

[3] Shih KS, Wang JH, Wu YW, Teng CM, Chen CC, Yang CR. Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes. PLoS One. 2012;7(7):e42389. doi: 10.1371/journal.pone.0042389. Epub 2012 Jul 31. PubMed PMID: 22860122; PubMed Central PMCID: PMC3409160.

[4] Shen CC, Cheng JJ, Lay HL, Wu SY, Ni CL, Teng CM, Chen CC. Cytotoxic apigenin derivatives from Chrysopogon aciculatis. J Nat Prod. 2012 Feb 24;75(2):198-201. doi: 10.1021/np2007796. Epub 2012 Jan 24. PubMed PMID: 22272829.

[5] Hsieh IN, Chang AS, Teng CM, Chen CC, Yang CR. Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways. J Biomed Sci. 2011 May 6;18:28. doi: 10.1186/1423-0127-18-28. PubMed PMID: 21548916; PubMed Central PMCID: PMC3113733.

6: Krause JA, Eggleston DS. Structure of 8-(2,6-dideoxy-beta-ribo-hexopyranosyl)-5-hydroxy-2-(4- hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one sesquihydrate, aciculatin. Acta Crystallogr C. 1991 Dec 15;47 ( Pt 12):2595-8. PubMed PMID: 1812914.

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