244291-63-2|AC-42|4-(4-butylpiperidin-1-yl)-1-(2-methylphenyl)butan-1-one|-范德生物科技公司

AC-42

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names：
4-(4-butylpiperidin-1-yl)-1-(2-methylphenyl)butan-1-one
CAS号：
244291-63-2
MDL Number：
MF(分子式)： C20H31NO MW(分子量)： 301.474
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AC-42
英文别名	AC-42
CAS号	244291-63-2
SMILES	O=C(C1=CC=CC=C1C)CCCN2CCC(CCCC)CC2
Inchi	InChI=1S/C20H31NO/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3
InchiKey	ANTKBACNWQHQJE-UHFFFAOYSA-N
分子式 Formula	C20H31NO
分子量 Molecular Weight	301.474
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AC-42(CAS:244291-63-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AC-42 is an M1 muscarinic receptor allosteric agonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[5] Gregory KJ, Sexton PM, Tobin AB, Christopoulos A. Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor. J Biol Chem. 2012 Oct 26;287(44):37066-77. doi: 10.1074/jbc.M112.408534. PubMed PMID: 22965232; PubMed Central PMCID: PMC3481307.

6: Kuo CL, Shiao AS, Liao WH, Ho CY, Lien CF. Can long-term hearing preservation be expected in children following cholesteatoma surgery? Results from a 14-year-long study of atticotomy-limited mastoidectomy with cartilage reconstruction. Audiol Neurootol. 2012;17(6):386-94. doi: 10.1159/000341985. PubMed PMID: 22948389.7: Daval SB, Valant C, Bonnet D, Kellenberger E, Hibert M, Galzi JL, Ilien B. Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. J Med Chem. 2012 Mar 8;55(5):2125-43. doi: 10.1021/jm201348t. PubMed PMID: 22329602.8: Markovic D, Holdich J, Al-Sabah S, Mistry R, Krasel C, Mahaut-Smith MP, Challiss RA. FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists. PLoS One. 2012;7(1):e29946. doi: 10.1371/journal.pone.0029946. PubMed PMID: 22272263; PubMed Central PMCID: PMC3260180.9: Jin Y, Kuznetsova T, Thijs L, Schmitz B, Liu Y, Asayama K, Brand SM, Heymans S, Brand E, Fagard R, Staessen JA. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens. 2012 Apr;25(4):472-8. doi: 10.1038/ajh.2011.244. PubMed PMID: 22237156.10: Ding XL, Deng YL, Zhang J, Miao LY. Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations. Genet Test Mol Biomarkers. 2011 Sep;15(9):659-62. doi: 10.1089/gtmb.2011.0010. PubMed PMID: 21510813.1

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