购物车 
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A 77003
- names：
L-Altritol, 1,2,5,6-tetradeoxy-2,5-bis(((2S)-3-methyl-2-(((methyl(2-pyrimidinylmethyl)amino)carbonyl)amino)-1-oxobutyl)amino)-1,6-diphenyl-
- CAS号：
134878-17-4
MDL Number： - MF(分子式)： C42H56N10O6 MW(分子量)： 796.97
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| FMK10516-100mg | 100mg | >98% | ¥ 0.00 | ¥ 0.00 | Get quote | ¥ 0.00 |
| 中文别名 | A 77003 |
| 英文别名 | A 77003; A-77003; A77003; Abbott 77003 |
| CAS号 | 134878-17-4 |
| Inchi | InChI=1S/C42H56N10O6/c1-27(2)35(49-41(57)51(5)25-33-43-19-13-20-44-33)39(55)47-31(23-29-15-9-7-10-16-29)37(53)38(54)32(24-30-17-11-8-12-18-30)48-40(56)36(28(3)4)50-42(58)52(6)26-34-45-21-14-22-46-34/h7-22,27-28,31-32,35-38,53-54H,23-26H2,1-6H3,(H,47,55)(H,48,56)(H,49,57)(H,50,58)/t31-,32-,35-,36-,37-,38+/m0/s1 |
| InchiKey | RMABAXSUFAXYMQ-ZXLHJDKKSA-N |
| 分子式 Formula | C42H56N10O6 |
| 分子量 Molecular Weight | 796.97 |
| 溶解度Solubility | |
| 性状 | Solid powder |
| 储藏条件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 产品说明 | A 77003(CAS:134878-17-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 |
| Introduction | A 77003 is an antiretroviral agent and HIV-1 protease inhibitor. A77003 impairs HIV-1 protease-mediated Gag processing, interferes with the assembly and maturation of the virus, and leads to an irreversible loss of the infectivity of the virus. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Bilello JA, Bilello PA, Kort JJ, Dudley MN, Leonard J, Drusano GL. Efficacy of constant infusion of A-77003, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, in limiting acute HIV-1 infection in vitro. Antimicrob Agents Chemother. 1995 Nov;39(11):2523-7. PubMed PMID: 8585738; PubMed Central PMCID: PMC162977. |
| [2]Drusano GL, Prichard M, Bilello PA, Bilello JA. Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation. Antimicrob Agents Chemother. 1996 May;40(5):1143-7. PubMed PMID: 8723455; PubMed Central PMCID: PMC163280. |
| [3] Ho DD, Toyoshima T, Mo H, Kempf DJ, Norbeck D, Chen CM, Wideburg NE, Burt SK, Erickson JW, Singh MK. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J Virol. 1994 Mar;68(3):2016-20. PubMed PMID: 8107264; PubMed Central PMCID: PMC236669. |
| [4] Rose RE, Gong YF, Greytok JA, Bechtold CM, Terry BJ, Robinson BS, Alam M, Colonno RJ, Lin PF. Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1648-53. PubMed PMID: 8643685; PubMed Central PMCID: PMC39996. |
| [5] Borman AM, Paulous S, Clavel F. Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J Gen Virol. 1996 Mar;77 ( Pt 3):419-26. PubMed PMID: 8601776. |
6: Kageyama S, Hoekzema DT, Murakawa Y, Kojima E, Shirasaka T, Kempf DJ, Norbeck DW, Erickson J, Mitsuya H. A C2 symmetry-based HIV protease inhibitor, A77003, irreversibly inhibits infectivity of HIV-1 in vitro. AIDS Res Hum Retroviruses. 1994 Jun;10(6):735-43. PubMed PMID: 8074936.7: Baldwin ET, Bhat TN, Liu B, Pattabiraman N, Erickson JW. Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase. Nat Struct Biol. 1995 Mar;2(3):244-9. PubMed PMID: 7773792.8: Mo H, Markowitz M, Majer P, Burt SK, Gulnik SV, Suvorov LI, Erickson JW, Ho DD. Design, synthesis, and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease. AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):55-61. PubMed PMID: 8825619.9: Gulnik SV, Suvorov LI, Liu B, Yu B, Anderson B, Mitsuya H, Erickson JW. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry. 1995 Jul 25;34(29):9282-7. PubMed PMID: 7626598.10: Kaplan AH, Michael SF, Wehbie RS, Knigge MF, Paul DA, Everitt L, Kempf DJ, Norbeck DW, Erickson JW, Swanstrom R. Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5597-601. PubMed PMID: 8202533; PubMed Central PMCID: PMC44043.1
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