96860-23-0|A 1110U|Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-|-范德生物科技公司

A 1110U

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names：
Carbonathioic dihydrazide, 2-((dimethylamino)thioxomethyl)-2'-(1-(2-pyridinyl)ethylidene)-
CAS号：
96860-23-0
MDL Number：
MF(分子式)： C11H16N6S2 MW(分子量)： 296.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	A 1110U
英文别名	A 1110U, A-1110U, A1110U
CAS号	96860-23-0
Inchi	InChI=1S/C11H16N6S2/c1-8(9-6-4-5-7-12-9)13-14-10(18)15-16-11(19)17(2)3/h4-7H,1-3H3,(H,16,19)(H2,14,15,18)/b13-8+
InchiKey	RPMMBVWROKDIKM-MDWZMJQESA-N
分子式 Formula	C11H16N6S2
分子量 Molecular Weight	296.41
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A 1110U(CAS:96860-23-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A 1110U is an inactivator of herpes simplex virus ribonucloetide reductases. It has been shown to be synergistic with acyclovir to produce chemotherapeutic effects on herpes skin lesions.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Porter DJ, Harrington JA, Spector T. Herpes simplex virus type 1ribonucleotide reductase: selective and synergistic inactivation by A1110U andits iron complex. Biochem Pharmacol. 1990 Feb 15;39(4):639-46. PubMed PMID:2154988.

[2]Ellis MN, Lobe DC, Spector T. Synergistic therapy by acyclovir and A1110U formice orofacially infected with herpes simplex viruses. Antimicrob AgentsChemother. 1989 Oct;33(10):1691-6. PubMed PMID: 2556074; PubMed Central PMCID:PMC172739.

[3] Spector T, Harrington JA, Porter DJ. Herpes and human ribonucleotidereductases. Inhibition by 2-acetylpyridine5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87). BiochemPharmacol. 1991 Jun 21;42(1):91-6. PubMed PMID: 1648925.

[4] Spector T, Harrington JA, Morrison RW Jr, Lambe CU, Nelson DJ, Averett DR,Biron K, Furman PA. 2-Acetylpyridine5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potentinactivator of ribonucleotide reductases of herpes simplex and varicella-zosterviruses and a potentiator of acyclovir. Proc Natl Acad Sci U S A. 1989Feb;86(3):1051-5. PubMed PMID: 2536930; PubMed Central PMCID: PMC286619.

[5] Lobe DC, Spector T, Ellis MN. Synergistic topical therapy by acyclovir andA1110U for herpes simplex virus induced zosteriform rash in mice. Antiviral Res.1991 Feb;15(2):87-100. PubMed PMID: 1650166.

6: Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM. Inactivators ofherpes simplex virus ribonucleotide reductase: hematological profiles and in vivopotentiation of the antiviral activity of acyclovir. Antimicrob Agents Chemother.1992 May;36(5):934-7. PubMed PMID: 1324641; PubMed Central PMCID: PMC188768.

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