108895-49-4|5-Et-ddU|2,4(1H,3H)-Pyrimidinedione, 5-ethyl-1-((2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl)-|-范德生物科技公司

5-Et-ddU

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names：
2,4(1H,3H)-Pyrimidinedione, 5-ethyl-1-((2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl)-
CAS号：
108895-49-4
MDL Number：
MF(分子式)： C11H16N2O4 MW(分子量)： 240.26
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5-Et-ddU
英文别名	5-Et-ddU; 5-Ethyl-2',3'-dideoxyuridine; D2EtU; ddEtUrd;
CAS号	108895-49-4
Inchi	InChI=1S/C11H16N2O4/c1-2-7-5-13(11(16)12-10(7)15)9-4-3-8(6-14)17-9/h5,8-9,14H,2-4,6H2,1H3,(H,12,15,16)/t8-,9+/m0/s1
InchiKey	MCKZMXMWYDOXBL-DTWKUNHWSA-N
分子式 Formula	C11H16N2O4
分子量 Molecular Weight	240.26
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	5-Et-ddU(CAS:108895-49-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	5-Et-ddU, Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. 3'-azido-2',3'-dideoxyuridine (5a), 3'-azido-5-ethyl-2',3'-dideoxyuridine (5c), and 3'-azido-2',3'-dideoxycytidine (7a) and its 5-methyl analogue (7b) were identified as potent and selective anti-HIV-1 agent in primary human lymphocytes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Srivastav NC, Shakya N, Bhavanam S, Agrawal A, Tse C, Desroches N, Kunimoto DY, Kumar R. Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1091-4. doi: 10.1016/j.bmcl.2011.11.114. Epub 2011 Dec 4. PubMed PMID: 22178557.

[2]Chu CK, Schinazi RF, Ahn MK, Ullas GV, Gu ZP. Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. J Med Chem. 1989 Mar;32(3):612-7. PubMed PMID: 2918508.

[3] Chu CK, Schinazi RF, Arnold BH, Cannon DL, Doboszewski B, Bhadti VB, Gu ZP. Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells. Biochem Pharmacol. 1988 Oct 1;37(19):3543-8. PubMed PMID: 3178868.

[4] Balzarini J, Baba M, Pauwels R, Herdewijn P, De Clerq E. Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues. Biochem Pharmacol. 1988 Jul 15;37(14):2847-56. PubMed PMID: 2840080.

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