1287205-42-8|2-PCCA|(1R,2R)-N-[(2S,3S)-2-Amino-3-methylpentyl]-N-(4'-propyl[1,1'-biphenyl]-4-yl)-2-(2-pyridinyl)-cyclopropanecarboxamide|-范德生物科技公司

2-PCCA

NMR下载 COA and HPLC MSDS下载
names：
(1R,2R)-N-[(2S,3S)-2-Amino-3-methylpentyl]-N-(4'-propyl[1,1'-biphenyl]-4-yl)-2-(2-pyridinyl)-cyclopropanecarboxamide
CAS号：
1287205-42-8
MDL Number：
MF(分子式)： C30H37N3O MW(分子量)： 455.65
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	2-PCCA
英文别名	2PCCA; 2 PCCA; 2-PCCA
CAS号	1287205-42-8
Inchi	InChI=1S/C30H37N3O/c1-4-8-22-10-12-23(13-11-22)24-14-16-25(17-15-24)33(20-28(31)21(3)5-2)30(34)27-19-26(27)29-9-6-7-18-32-29/h6-7,9-18,21,26-28H,4-5,8,19-20,31H2,1-3H3/t21-,26+,27+,28+/m0/s1
InchiKey	OBGKRTYDTRUMGO-RFNYNIMXSA-N
分子式 Formula	C30H37N3O
分子量 Molecular Weight	455.65
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	2-PCCA(CAS:1287205-42-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	2-PCCA is a GPR88 agonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Li JX, Thorn DA, Jin C. The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7. doi: 10.1016/j.ejphar.2012.10.037. Epub 2012 Nov 2. PubMed PMID: 23123351.

[2]Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. doi: 10.1021/cn500082p. Epub 2014 May 14. PubMed PMID: 24793972; PubMed Central PMCID: PMC4102971.

[3] Jin C, Decker AM, Harris DL, Blough BE. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. Epub 2016 Aug 16. PubMed PMID: 27499251; PubMed Central PMCID: PMC5071162.

[4] Jin C, Decker AM, Langston TL. Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists. Bioorg Med Chem. 2017 Jan 15;25(2):805-812. doi: 10.1016/j.bmc.2016.11.058. Epub 2016 Dec 1. PubMed PMID: 27956039; PubMed Central PMCID: PMC5218591.

[5] Decker AM, Gay EA, Mathews KM, Rosa TC, Langston TL, Maitra R, Jin C. Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88. J Biomed Sci. 2017 Mar 27;24(1):23. doi: 10.1186/s12929-017-0330-3. PubMed PMID: 28347302; PubMed Central PMCID: PMC5369193.

6: Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R. Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. J Med Chem. 2018 Aug 9;61(15):6748-6758. doi: 10.1021/acs.jmedchem.8b00566. Epub 2018 Jul 30. PubMed PMID: 30011199; PubMed Central PMCID: PMC6108082.7: Ye N, Li B, Mao Q, Wold EA, Tian S, Allen JA, Zhou J. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target. ACS Chem Neurosci. 2018 Dec 12. doi: 10.1021/acschemneuro.8b00572. [Epub ahead of print] PubMed PMID: 30540906.

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