57818-88-9|1-Deaza-fad|Adenosine 5'-(trihydrogen diphosphate), 5-5'-ester with 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxopyrimido(4,5-b)quinolin-10(2H)-yl)-D-ribitol|-范德生物科技公司

1-Deaza-fad

NMR下载 COA and HPLC MSDS下载
names：
Adenosine 5'-(trihydrogen diphosphate), 5-5'-ester with 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxopyrimido(4,5-b)quinolin-10(2H)-yl)-D-ribitol
CAS号：
57818-88-9
MDL Number：
MF(分子式)： C28H34N8O15P2 MW(分子量)： 784.568
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	1-Deaza-fad
英文别名	1-Deaza-fad; Deazafad; 1-deazaFAD ; 5-Deazariboflavin-5'-diphosphate.
CAS号	57818-88-9
SMILES	n1c2n(c3cc(c(cc3cc2c([nH]c1=O)=O)C)C)C[C@H](O)[C@H](O)[C@@H](CO[P@@](=O)(O)O[P@@](=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O1)n1cnc2c(N)ncnc12)O
Inchi	1S/C28H34N8O15P2/c1-11-3-13-5-14-24(33-28(43)34-26(14)42)35(15(13)4-12(11)2)6-16(37)20(39)17(38)7-48-52(44,45)51-53(46,47)49-8-18-21(40)22(41)27(50-18)36-10-32-19-23(29)30-9-31-25(19)36/h3-5,9-10,16-18,20-22,27,37-41H,6-8H2,1-2H3,(H,44,45)(H,46,47)(H2,29,30,31)(H,34,42,43)/t16-,17+,18+,20-,21+,22+,27+/m0/s1
InchiKey	GLDULYQMIPGSPD-AUSFFQRRSA-N
分子式 Formula	C28H34N8O15P2
分子量 Molecular Weight	784.568
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	1-Deaza-fad(CAS:57818-88-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	1-Deaza-fad also known as Deazafad. 1-deazaFAD has comparable activity in the mutase reconstituted.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Hassan-Abdallah A, Zhao G, Jorns MS. Role of the covalent flavin linkage in monomeric sarcosine oxidase. Biochemistry. 2006 Aug 8;45(31):9454-62. PubMed PMID: 16878980.

[2]Hassan-Abdallah A, Bruckner RC, Zhao G, Jorns MS. Biosynthesis of covalently bound flavin: isolation and in vitro flavinylation of the monomeric sarcosine oxidase apoprotein. Biochemistry. 2005 May 3;44(17):6452-62. PubMed PMID: 15850379; PubMed Central PMCID: PMC1993914.

[3] Huang Z, Zhang Q, Liu HW. Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Bioorg Chem. 2003 Dec;31(6):494-502. PubMed PMID: 14613770.

[4] Zhang H, Gruenke L, Arscott D, Shen A, Kasper C, Harris DL, Glavanovich M, Johnson R, Waskell L. Determination of the rate of reduction of oxyferrous cytochrome P450 2B4 by 5-deazariboflavin adenine dinucleotide T491V cytochrome P450 reductase. Biochemistry. 2003 Oct 14;42(40):11594-603. PubMed PMID: 14529269.

[5] Zhang H, Gruenke L, Saribas AS, Im SC, Shen AL, Kasper CB, Waskell L. Preparation and characterization of a 5'-deazaFAD T491V NADPH-cytochrome P450 reductase. Biochemistry. 2003 Jun 10;42(22):6804-13. PubMed PMID: 12779335.

6: Poinas A, Gaillard J, Vignais P, Doussiere J. Exploration of the diaphorase activity of neutrophil NADPH oxidase. Eur J Biochem. 2002 Feb;269(4):1243-52. PubMed PMID: 11856358.7: Rudik I, Thorpe C. Thioester enolate stabilization in the acyl-CoA dehydrogenases: the effect of 5-deaza-flavin substitution. Arch Biochem Biophys. 2001 Aug 15;392(2):341-8. PubMed PMID: 11488611.8: Dwyer TM, Mortl S, Kemter K, Bacher A, Fauq A, Frerman FE. The intraflavin hydrogen bond in human electron transfer flavoprotein modulates redox potentials and may participate in electron transfer. Biochemistry. 1999 Jul 27;38(30):9735-45. PubMed PMID: 10423253.9: Harris CM, Sanders SA, Massey V. Role of the flavin midpoint potential and NAD binding in determining NAD versus oxygen reactivity of xanthine oxidoreductase. J Biol Chem. 1999 Feb 19;274(8):4561-9. PubMed PMID: 9988690.10: Tedeschi G, Chen S, Massey V. Active site studies of DT-diaphorase employing artificial flavins. J Biol Chem. 1995 Feb 10;270(6):2512-6. PubMed PMID: 7531691.1

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