132449-46-8|Lesopitron|2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine|-范德生物科技公司

Lesopitron

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names：
2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine
CAS号：
132449-46-8
MDL Number：
MF(分子式)： C15H21ClN6 MW(分子量)： 320.82
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lesopitron
英文别名	Lesopitron;
CAS号	132449-46-8
Inchi	InChI=1S/C15H21ClN6/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15/h3-5,12-13H,1-2,6-11H2
InchiKey	AHCPKWJUALHOPH-UHFFFAOYSA-N
分子式 Formula	C15H21ClN6
分子量 Molecular Weight	320.82
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lesopitron(CAS:132449-46-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lesopitron acts as a ligand for central serotonin 5-HT1A receptors.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fisas MA, Farré A, Camarasa J, Escubedo E. Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. Pharmacology. 2004 Oct;72(2):57-67. PubMed PMID: 15331910.

[2]Fresquet A, Sust M, Lloret A, Murphy MF, Carter FJ, Campbell GM, Marion-Landais G. Efficacy and safety of lesopitron in outpatients with generalized anxiety disorder. Ann Pharmacother. 2000 Feb;34(2):147-53. PubMed PMID: 10676820.

[3] Phillips MA, Szabadi E, Bradshaw CM. The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1A receptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone. J Psychopharmacol. 1999 Dec;13(4):391-7. PubMed PMID: 10667616.

[4] Sramek JJ, Fresquet A, Marion-Landais G, Hourani J, Jhee SS, Martinez L, Jensen CM, Bolles K, Carrington AT, Cutler NR. Establishing the maximum tolerated dose of lesopitron in patients with generalized anxiety disorder: a bridging study. J Clin Psychopharmacol. 1996 Dec;16(6):454-8. PubMed PMID: 8959472.

[5] Haj-Dahmane S, Jolas T, Laporte AM, Gozlan H, Farré AJ, Hamon M, Lanfumey L. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. Eur J Pharmacol. 1994 Apr 1;255(1-3):185-96. PubMed PMID: 8026543.

6: Micheli F. Lesopitron (Esteve). IDrugs. 2001 Feb;4(2):218-24. PubMed PMID: 16032484.7: Serafini MT, Puig S, García-Encina G, Farran R, García-Soret A, Moragon T, Martínez L. Absorption, distribution and excretion of [14C]-Lesopitron after single and repeated administration in rats and dogs. Methods Find Exp Clin Pharmacol. 1997 Jan-Feb;19(1):61-72. Erratum in: Methods Find Exp Clin Pharmacol 1997 Apr;19(3):212. PubMed PMID: 9098842.8: Palacios G, Muro MA, Paz Marín A. Differential effects of haloperidol and two anxiolytic drugs, buspirone and lesopitron, on c-Fos expression in the rat striatum and nucleus accumbens. Brain Res. 1996 Dec 2;742(1-2):141-8. PubMed PMID: 9117387.9: García-Encina G, Farrán R, Puig S, Serafini MT, Martínez L. Automated high-performance liquid chromatographic assay for lesopitron, a novel anxiolytic, in human plasma using on-line solid-phase extraction. J Chromatogr B Biomed Appl. 1995 Aug 4;670(1):103-10. PubMed PMID: 7493067.10: Ballarín M, Carceller A, Guitart X. Effect of acute administration of the 5-HT1A receptor ligand, lesopitron, on rat cortical 5-HT and dopamine turnover. Br J Pharmacol. 1994 Oct;113(2):425-30. PubMed PMID: 7530571; PubMed Central PMCID: PMC1510099.1

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