144285-77-8|Skf 107457|methyl ((1S,2S)-2-((S)-2-((S)-2-aminopropanamido)propanamido)-1-hydroxy-3-phenylpropyl)glycyl-L-valyl-L-valinate|-范德生物科技公司

Skf 107457

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names：
methyl ((1S,2S)-2-((S)-2-((S)-2-aminopropanamido)propanamido)-1-hydroxy-3-phenylpropyl)glycyl-L-valyl-L-valinate
CAS号：
144285-77-8
MDL Number：
MF(分子式)： C28H46N6O7 MW(分子量)： 578.71
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl ((1S,2S)-2-((S)-2-((S)-2-aminopropanamido)propanamido)-1-hydroxy-3-phenylpropyl)glycyl-L-valyl-L-valinate
英文别名	Skf 107457; Skf-107457; Skf107457;
CAS号	144285-77-8
Inchi	InChI=1S/C28H46N6O7/c1-15(2)22(27(39)34-23(16(3)4)28(40)41-7)33-21(35)14-30-26(38)20(13-19-11-9-8-10-12-19)32-25(37)18(6)31-24(36)17(5)29/h8-12,15-18,20,22-23,26,30,38H,13-14,29H2,1-7H3,(H,31,36)(H,32,37)(H,33,35)(H,34,39)/t17-,18-,20-,22-,23-,26-/m0/s1
InchiKey	LGMKNRQKNYJXMF-ZMHIJFKWSA-N
分子式 Formula	C28H46N6O7
分子量 Molecular Weight	578.71
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Skf 107457(CAS:144285-77-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Skf 107457 is a hexapeptide substrate analogue with the scissile bond being replaced by a hydroxyethylene isostere.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J Biol Chem. 1992 Nov 15;267(32):22770-8. PubMed PMID: 1429626.

[2]Wood SJ, Wetzel R. A novel method for the incorporation of glycoprotein-derived oligosaccharides into neoglycopeptides. Bioconjug Chem. 1992 Sep-Oct;3(5):391-6. PubMed PMID: 1420438.

[3] Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 199

6:638-52. PubMed PMID: 9390264.

[5] Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry. 1993 Dec 7;32(48):13054-60. PubMed PMID: 8241159.

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