101932-71-2|Calyculin A|Calyculin A, protein phosphatase inhibitor|-范德生物科技公司

Calyculin A

NMR下载 COA and HPLC MSDS下载
names：
Calyculin A, protein phosphatase inhibitor
CAS号：
101932-71-2
MDL Number：
MF(分子式)： C50H81N4O15P MW(分子量)： 1009.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

Calyculin A, protein phosphatase inhibitor（101932-71-2）是一种强效、选择性和细胞渗透性蛋白磷酸酶抑制剂（PP1 和 PP2A 的 IC50 值分别为 2 和 1 nM）。对 PP2B 和 PP2C 具有高度选择性。在体内和体外都有活性。

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询价

中文别名	Calyculin A;Calyculin-A;protein phosphatase inhibitor；蛋白磷酸酶抑制剂；protein phosphatase inhibitor
英文别名	Calyculin A; Hemicalyculin A;
CAS号	101932-71-2
Inchi	InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
InchiKey	FKAWLXNLHHIHLA-YCBIHMBMSA-N
分子式 Formula	C50H81N4O15P
分子量 Molecular Weight	1009.18
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

Calyculin A, protein phosphatase inhibitor - Functional Studies
Calyculin A 抑制乳腺癌上皮 MCF7 细胞的生长。将细胞与不同浓度的 Calyculin A 一起孵育四天。细胞数采用亚甲蓝法测定。相对于对照 (100%) 对细胞数进行标准化，并针对 Calyculin A 浓度作图。

产品说明	Calyculin A（101932-71-2）是一种强效、选择性和细胞渗透性蛋白磷酸酶抑制剂（PP1 和 PP2A 的 IC50 值分别为 2 和 1 nM）。对 PP2B 和 PP2C 具有高度选择性。在体内和体外都有活性。
Introduction	Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively). It is without significant effect against PP2B, PP2C, and PP4.2 Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wakimoto T, Egami Y, Nakashima Y, Wakimoto Y, Mori T, Awakawa T, Ito T, Kenmoku H, Asakawa Y, Piel J, Abe I. Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont. Nat Chem Biol. 2014 Aug;10(8):648-55. doi: 10.1038/nchembio.1573. Epub 2014 Jun 29. PubMed PMID: 24974231.

[2]Almasry M, Jemaà M, Mischitelli M, Faggio C, Lang F. Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A. Cell Physiol Biochem. 2016;40(1-2):163-171. Epub 2016 Nov 18. PubMed PMID: 27855413.

[3] Chartier L, Rankin LL, Allen RE, Kato Y, Fusetani N, Karaki H, Watabe S, Hartshorne DJ. Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts. Cell Motil Cytoskeleton. 1991;18(1):26-40. PubMed PMID: 1848484.

[4] Edelson JR, Brautigan DL. The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells. Toxins (Basel). 2011 Jan;3(1):105-19. doi: 10.3390/toxins3010105. Epub 2011 Jan 24. PubMed PMID: 22069692; PubMed Central PMCID: PMC3210456.

[5] Gutierrez LM, Quintanar JL, Rueda J, Viniegra S, Reig JA. The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells. Eur J Cell Biol. 1995 Sep;68(1):88-95. PubMed PMID: 8549595.

6: Holy M, Brautigan DL. Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases. Toxins (Basel). 2012 Oct;4(10):940-54. doi: 10.3390/toxins4100940. Epub 2012 Oct 22. PubMed PMID: 23162706; PubMed Central PMCID: PMC3496997.7: Leopoldt D, Yee HF Jr, Rozengurt E. Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. J Cell Physiol. 2001 Jul;188(1):106-19. PubMed PMID: 11382927.8: Pozuelo-Rubio M, Leslie NR, Murphy J, Mackintosh C. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A. Cell Biochem Biophys. 2010 Dec;58(3):147-56. doi: 10.1007/s12013-010-9101-4. PubMed PMID: 20717744; PubMed Central PMCID: PMC3627045.9: Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang JZ, Wang X. Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. J Alzheimers Dis. 2011;24(3):525-35. doi: 10.3233/JAD-2011-101779. PubMed PMID: 21297267.10: Kramer JM, Evans A, Drury K, Moore K. Calyculin-A improves chromosome condensation for cytogenetic analysis of blastomeres from bovine and murine eight-cell stage embryos. Theriogenology. 2008 Sep 1;70(4):692-703. doi: 10.1016/j.theriogenology.2008.04.048. Epub 2008 Jun 16. PubMed PMID: 18556054.1

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