164931-25-3|SC-58272|(2S)-6-amino-N-(2-cyclohexylethyl)-2-[[(2S)-3-hydroxy-2-[[2-[4-[4-(2-methylimidazol-1-yl)butyl]phenyl]acetyl]amino]propanoyl]amino]hexanamide|-范德生物科技公司

SC-58272

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names：
(2S)-6-amino-N-(2-cyclohexylethyl)-2-[[(2S)-3-hydroxy-2-[[2-[4-[4-(2-methylimidazol-1-yl)butyl]phenyl]acetyl]amino]propanoyl]amino]hexanamide
CAS号：
164931-25-3
MDL Number：
MF(分子式)： C33H52N6O4 MW(分子量)： 596.817
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2S)-6-amino-N-(2-cyclohexylethyl)-2-[[(2S)-3-hydroxy-2-[[2-[4-[4-(2-methylimidazol-1-yl)butyl]phenyl]acetyl]amino]propanoyl]amino]hexanamide
英文别名	SC-58272; SC 58272; SC58272.
CAS号	164931-25-3
SMILES	NCCCC[C@@H](C(N)=O)N(C([C@H](CO)NC(CC1=CC=C(CCCCN2C=CN=C2C)C=C1)=O)=O)CCC3CCCCC3
Inchi	InChI=1S/C33H52N6O4/c1-25-36-19-22-38(25)20-8-6-11-27-13-15-28(16-14-27)23-31(41)37-29(24-40)33(43)39(21-17-26-9-3-2-4-10-26)30(32(35)42)12-5-7-18-34/h13-16,19,22,26,29-30,40H,2-12,17-18,20-21,23-24,34H2,1H3,(H2,35,42)(H,37,41)/t29-,30-/m0/s1
InchiKey	BUDUJVHIPNDQKY-KYJUHHDHSA-N
分子式 Formula	C33H52N6O4
分子量 Molecular Weight	596.817
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SC-58272(CAS:164931-25-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SC-58272 is an antifungal NMT inhibitor. N-myristoyltransferase (Nmt) attaches myristate to the N-terminal glycine of many important eukaryotic and viral proteins. It is a target for anti-fungal and anti-viral therapy.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sheng CQ, Zhu J, Zhang WN, Xu H, Miao ZY, Yao JZ, Zhang M. [Evolutionary trace analysis of N-myristoyltransferase family]. Yao Xue Xue Bao. 2007 Feb;42(2):157-65. Chinese. PubMed PMID: 17518043.

[2]Sogabe S, Masubuchi M, Sakata K, Fukami TA, Morikami K, Shiratori Y, Ebiike H, Kawasaki K, Aoki Y, Shimma N, D'Arcy A, Winkler FK, Banner DW, Ohtsuka T. Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol. 2002 Oct;9(10):1119-28. PubMed PMID: 12401496.

[3] Farazi TA, Waksman G, Gordon JI. Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry. 2001 May 29;40(21):6335-43. PubMed PMID: 11371195.

[4] Fütterer K, Murray CL, Bhatnagar RS, Gokel GW, Gordon JI, Waksman G. Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA. Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):393-400. PubMed PMID: 11223516.

[5] Bhatnagar RS, Fütterer K, Farazi TA, Korolev S, Murray CL, Jackson-Machelski E, Gokel GW, Gordon JI, Waksman G. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs. Nat Struct Biol. 1998 Dec;5(12):1091-7. PubMed PMID: 9846880.

6: Lodge JK, Jackson-Machelski E, Devadas B, Zupec ME, Getman DP, Kishore N, Freeman SK, McWherter CA, Sikorski JA, Gordon JI. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. Microbiology. 1997 Feb;143 ( Pt 2):357-66. PubMed PMID: 9043113.7: Zhang L, Jackson-Machelski E, Gordon JI. Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants. J Biol Chem. 1996 Dec 20;271(51):33131-40. PubMed PMID: 8955162.

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