11079-53-1|Hyperforin dicyclohexylammonium salt|Hyperforin dicyclohexylammonium salt|-范德生物科技公司

Hyperforin dicyclohexylammonium salt

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names：
Hyperforin dicyclohexylammonium salt
CAS号：
11079-53-1
MDL Number：
MF(分子式)： C35H52O4 MW(分子量)： 536.797
EINECS: Reaxys Number:
Pubchem ID:46926346 Brand:BIOFOUNT

Hyperforin dicyclohexylammonium salt(11079-53-1)是类固醇 X 受体的天然激活剂（活性为 0.1 至 0.5 µg/ml）和几种细胞色素 P450 (CYP) 同种型的抑制剂（CYP2D6 的 IC50 = 10 µg/ml）。它还可以抑制微粒体前列腺素 E2 synthase-1 (mPGES-1; IC50 = 1 µM)、5-脂氧合酶激活蛋白和 sirtuins。

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DBK501003-100mg	100mg		¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Hyperforin dicyclohexylammonium salt(11079-53-1);贯叶金丝桃素
英文别名	Hyperforin dicyclohexylammonium salt(11079-53-1);Hyperforin
CAS号	11079-53-1
SMILES	CC(C)C(=O)[C@@]12C(O)=C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O
Inchi	InChI=1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-
InchiKey	ZUYCAROZOLUHJY-DNSWOBEMSA-N
分子式 Formula	C35H52O4
分子量 Molecular Weight	536.797
闪点 FP	NA
熔点 Melting point	NA
沸点 Boiling point	NA
Polarizability极化度	No data available
密度 Density	NA
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid,Powder
储藏条件 Storage conditions	Store at -20°C. Store In the Dark. Store under desiccating conditions.

Hyperforin使用注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

产品说明	Hyperforin dicyclohexylammonium salt(11079-53-1)是类固醇 X 受体的天然激活剂（活性为 0.1 至 0.5 μg/ml）和几种细胞色素 P450 (CYP) 同种型的抑制剂（CYP2D6 的 IC50 = 10 μg/ml）。
Introduction	Hyperforin dicyclohexylammonium salt(11079-53-1) is a natural activator of the steroid X receptor (activity 0.1 to 0.5 μg/ml) and an inhibitor of several cytochrome P450 (CYP) isoforms
Application1	Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate, with IC50 values of 0.05-0.10 mcg/ml for all compounds, with the exception of glutamate, which is in the 0.5 mcg/ml range. It appears to exert these effects by activating the transient receptor potential ion channel TRPC6. Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake.TargetActionsOrganismUProstaglandin G/H synthase 1inhibitorHumansUNuclear receptor subfamily 1 group I member 2Not AvailableHumansUArachidonate 5-lipoxygenaseinhibitorHumans
Application2
Application3

警示图
危险性
危险性警示	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
安全声明	H315 H319 H335
安全防护	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
备注	实验过程中防止吸入、食如，做好安全防护

1. Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. J. Endocrinol. 166, R11-R16 (2000).

2. Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. J. Pharmacol. Exp. Ther. 294(1), 88-95 (2000).

3. Chang, H.H., and Meuillet, E.J. Identification and development of mPGES-1 inhibitors: Where we are at? Future Med. Chem. 3(15), 1909-1934 (2011).

4.Tao R et al. Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs. J Mol Cell Biol 12:807-816 (2020).

5. Milne, J.C., and Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 12, 11-17 (2008).

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