145216-43-9|Forasartan|5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine|-范德生物科技公司

Forasartan

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names：
5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine
CAS号：
145216-43-9
MDL Number：
MF(分子式)： C23H28N8 MW(分子量)： 416.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Forasartan
英文别名	Forasartan; SC-52458; SC 52458; SC52458.
CAS号	145216-43-9
SMILES	CCCCC1=NN(C(=N1)CCCC)CC2=CN=C(C=C2)C3=CC=CC=C3C4=NNN=N4
Inchi	InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)
InchiKey	YONOBYIBNBCDSJ-UHFFFAOYSA-N
分子式 Formula	C23H28N8
分子量 Molecular Weight	416.52
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Forasartan(CAS:145216-43-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T.Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNAexpression by high-frequency preganglionic stimulation at the canine cardiacsympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482.

[2]Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role ofbasally synthesized nitric oxide in modulating the renal vasoconstrictor actionof angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259.

[3] McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS.Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am JHypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514.

[4] Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin IIreceptor antagonist, on increase in cytoplasmic Ca2+ concentrations andcontraction induced by angiotensin II and K(+)-depolarization in guinea-pigtaenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065.

[5] Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H. Role ofangiotensin II in extracellular matrix and transforming growth factor-beta 1expression in hypertensive rats. Eur J Pharmacol. 1994 Sep 15;269(1):115-9.PubMed PMID: 7828653.

6: Olins GM, Corpus VM, Chen ST, McMahon EG, Palomo MA, McGraw DE, Smits GJ, NullCL, Brown MA, Bittner SE, et al. Pharmacology of SC-52458, an orally active,nonpeptide angiotensin AT1 receptor antagonist. J Cardiovasc Pharmacol. 1993Oct;22(4):617-25. PubMed PMID: 7505365.7: de la Hoz JC. [Bee (Apis mellifera, Hymenoptera: Apoidea) visitation tocantaloupe Cucumis melo (Cucurvitaceae) flowers in Panama]. Rev Biol Trop. 2007Jun;55(2):677-80. Spanish. PubMed PMID: 19069779.8: Krovat EM, Langer T. Non-peptide angiotensin II receptor antagonists: chemicalfeature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26.PubMed PMID: 12593652.9: Katsuragi T, Sato C, Guangyuan L, Honda K. Inositol(1,4,5)trisphosphate signaltriggers a receptor-mediated ATP release. Biochem Biophys Res Commun. 2002 May3;293(2):686-90. PubMed PMID: 12054523.10: Hagmann M, Nussberger J, Naudin RB, Burns TS, Karim A, Waeber B, Brunner HR.SC-52458, an orally active angiotensin II-receptor antagonist: inhibition ofblood pressure response to angiotensin II challenges and pharmacokinetics innormal volunteers. J Cardiovasc Pharmacol. 1997 Apr;29(4):444-50. PubMed PMID:9156352.1

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