77-27-0|Thiamylal|5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione|-范德生物科技公司

Thiamylal

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names：
5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS号：
77-27-0
MDL Number：
MF(分子式)： C12H18N2O2S MW(分子量)： 254.348
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
英文别名	Thiamylal; Thioseconal; Surital; Thioquinalbarbitone.
CAS号	77-27-0
SMILES	O=C(C1(C(CCC)C)CC=C)NC(NC1=O)=S
Inchi	InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
InchiKey	XLOMZPUITCYLMJ-UHFFFAOYSA-N
分子式 Formula	C12H18N2O2S
分子量 Molecular Weight	254.348
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Thiamylal(CAS:77-27-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia or as an anticonvulsant to counteract side effects from other anaesthetics. It is the thiobarbiturate analogue of secobarbital. Thiamylal is discontinued.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wu RS, Yu CS, Liu KC, Huang HY, Ip SW, Lin JP, Chueh FS, Yang JS, Chung JG. Citosol (thiamylal sodium) triggers apoptosis and affects gene expressions of murine leukemia RAW 264.7 cells. Hum Exp Toxicol. 2012 Aug;31(8):771-9. doi: 10.1177/0960327111429137. PubMed PMID: 22895347.

[2]Higashijima U, Terao Y, Ichinomiya T, Miura K, Fukusaki M, Sumikawa K. A comparison of the effect on QT interval between thiamylal and propofol during anaesthetic induction*. Anaesthesia. 2010 Jul;65(7):679-83. doi: 10.1111/j.1365-2044.2010.06341.x. Epub 2010 May 28. PubMed PMID: 20528837.

[3] Lin CK, Lau YW, Chan HM, Wang FY, Lin TJ, Cheng KI, Feng YT, Hung CL. Intravenous thiamylal and local anesthetic infiltration for pediatric facial repair procedures performed in emergency departments. Kaohsiung J Med Sci. 2010 Apr;26(4):192-9. doi: 10.1016/S1607-551X(10)70028-0. PubMed PMID: 20434100.

[4] Hidaka I, Kurokawa H, Yasuda T, Hamada H, Kawamoto M, Yuge O. Thiamylal and thiopental attenuate beta-adrenergic signaling pathway by suppressing adenylyl cyclase in rat ventricular myocytes. Hiroshima J Med Sci. 2009 Mar;58(1):9-15. PubMed PMID: 19400552.

[5] Tanaka E, Tobita T, Murai Y, Okabe Y, Yamada A, Kano T, Higashi H, Shimoji K. Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans. Neurosci Res. 2009 Aug;64(4):391-6. doi: 10.1016/j.neures.2009.04.012. Epub 2009 Apr 23. PubMed PMID: 19393696.

6: Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatr Taiwan. 2005 Sep-Oct;46(5):294-300. PubMed PMID: 16640004.7: Iwata S, Okumura A, Kato T, Itomi K, Kuno K. Efficacy and adverse effects of rectal thiamylal with oral triclofos for children undergoing magnetic resonance imaging. Brain Dev. 2006 Apr;28(3):175-7. Epub 2005 Dec 20. PubMed PMID: 16368209.8: Atwal OS, McDonell W. In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: a comparative ultrastructural and cytochemical study. Anat Rec A Discov Mol Cell Evol Biol. 2005 Jun;284(2):574-84. PubMed PMID: 15880489.9: Eguchi S, Kawano T, Oshita S, Nakajo N. [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells]. Masui. 2005 Apr;54(4):364-9. Japanese. PubMed PMID: 15852621.10: Tomari S, Matsuse H, Ootsubo T, Miyazaki Y, Kohno S. [A survival case of tetanus complicated with disseminated intravascular coagulation syndrome in the elderly, rescued by mechanical ventilation and administration of thiamylal]. Kansenshogaku Zasshi. 2005 Jan;79(1):25-8. Japanese. PubMed PMID: 15717480.1

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