309-29-5|Doxapram|1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one|-范德生物科技公司

Doxapram

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names：
1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one
CAS号：
309-29-5
MDL Number：
MF(分子式)： C24H30N2O2 MW(分子量)： 378.516
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Doxapram
英文别名	AHR-619; AHR 619; AHR619; Doxapram; Doxapram hydrochloride, Brand name Dopram, Stimulex or Respiram.
CAS号	309-29-5
SMILES	O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4
Inchi	InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
InchiKey	XFDJYSQDBULQSI-UHFFFAOYSA-N
分子式 Formula	C24H30N2O2
分子量 Molecular Weight	378.516
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	White to off-white crystalline powder.
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Doxapram(CAS:309-29-5 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Doxapram is a respiratory stimulant. Administered intravenously, Doxapram stimulates an increase in tidal volume and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. Doxapram induced changes in the electrophysiological properties of pre-inspiratory and inspiratory neurones. Results suggest that respiratory activity enhancement was likely to be induced via effects on the potassium channels of pre-inspiratory and inspiratory neurones and indicate the central actions of doxapram.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Martinez JM, Garakani A, Aaronson CJ, Gorman JM. Heart rate and respiratory response to doxapram in patients with panic disorder. Psychiatry Res. 2015 May 30;227(1):32-8. doi: 10.1016/j.psychres.2015.03.00[1]Epub 2015 Mar 9. PubMed PMID: 25819170; PubMed Central PMCID: PMC4420657.

[2]Wang HL, Tang SH, Wang XQ, Gong WH, Liu XM, Lei WF. Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil. Exp Ther Med. 2015 Apr;9(4):1518-1522. Epub 2015 Feb 2. PubMed PMID: 25780462; PubMed Central PMCID: PMC4353763.

[3] Ogawa Y, Irikura M, Kobaru Y, Tomiyasu M, Kochiyama Y, Uriu M, Ishitsuka Y, Kondo Y, Yukawa E, Kamada N, Ohno H, Yamazaki T, Irie T. Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18. doi: 10.1007/s00431-014-2416-1. Epub 2014 Sep 25. PubMed PMID: 25248340.

[4] Czaba-Hnizdo C, Olischar M, Rona Z, Weninger M, Berger A, Klebermass-Schrehof K. Amplitude-integrated electroencephalography shows that doxapram influences the brain activity of preterm infants. Acta Paediatr. 2014 Sep;103(9):922-7. doi: 10.1111/apa.12681. Epub 2014 May 27. PubMed PMID: 24813556.

[5] Osaka Y, Onimaru H, Kotani S, Kashiwagi M, Morisaki H, Takeda J. The effects of doxapram on medullary respiratory neurones in brainstem-spinal cord preparations from newborn rats. Anaesthesia. 2014 May;69(5):468-75. doi: 10.1111/anae.12590. Epub 2014 Mar 7. PubMed PMID: 24601902.

6: Oikawa S, Nomura H, Nishio M, Nagata R, Hata T. Doxapram hydrochloride aggravates adrenaline-induced arrhythmias accompanied by bidirectional ventricular tachycardia. ISRN Cardiol. 2014 Jan 9;201

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