52365-63-6|Dipivefrin|4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene bis(2,2-dimethylpropanoate)|-范德生物科技公司

Dipivefrin

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names：
4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene bis(2,2-dimethylpropanoate)
CAS号：
52365-63-6
MDL Number：
MF(分子式)： C19H29NO5 MW(分子量)： 351.4373
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK14640-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Dipivefrin
英文别名	K 30081; K30081; K-30081; Dipivefrin; Dipivefrinum; Dipivefrina
CAS号	52365-63-6
Inchi	InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
InchiKey	OCUJLLGVOUDECM-UHFFFAOYSA-N
分子式 Formula	C19H29NO5
分子量 Molecular Weight	351.4373
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dipivefrin(CAS:52365-63-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Groh MJ, Michelson G, Harazny J, Groh M, Koschinsky K. [Changes in retinal blood flow by topical administration of 0.1% dipivefrin]. Ophthalmologe. 1999 Nov;96(11):706-10. German. PubMed PMID: 10631832.

[2]Edgar DF, Crabb DP, Rudnicka AR, Lawrenson JG, Guttridge NM, O'Brien CJ. Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity. Graefes Arch Clin Exp Ophthalmol. 1999 Feb;237(2):117-24. PubMed PMID: 9987628.

[3] Rossetti L, Barbieri P, Velati P, Bujtar E, Orzalesi N. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4. PubMed PMID: 7843592.

[4] Michelson G, Groh MJ. Dipivefrin reduces blood flow in the ciliary body in humans. Ophthalmology. 1994 Apr;101(4):659-64. PubMed PMID: 8152760.

[5] Albracht DC, LeBlanc RP, Cruz AM, Lamping KA, Siegel LI, Stern KL, Kelley EP, Stoecker JF. A double-masked comparison of betaxolol and dipivefrin for the treatment of increased intraocular pressure. Am J Ophthalmol. 1993 Sep 15;116(3):307-13. PubMed PMID: 8357055.

6: Drake MV, Wilson MR, Harris D, Goodwin L. Levobunolol compared to dipivefrin in African American patients with open angle glaucoma. J Ocul Pharmacol. 1993 Summer;9(2):91-5. Erratum in: J Ocul Pharmacol 1993 Winter;9(4):385. PubMed PMID: 8123096.7: Wall GM, Kenny JC, Fan TY, Schafer C, Ready MA, Baker JK, Ritter P, Scott BS. Analysis of 3- and 4-monopivaloylepinephrine, degradation products in dipivefrin hydrochloride drug substance and ophthalmic formulations. J Pharm Biomed Anal. 1992 Jun;10(6):465-71. PubMed PMID: 1420470.8: Satterfield D, Mannis MJ, Glover AT. Unilateral corneal vesicles secondary to dipivefrin therapy. Am J Ophthalmol. 1992 Mar 15;113(3):339-40. PubMed PMID: 1543234.9: Geyer O, Rothkoff L, Lazar M. Efficacy of adding dipivefrin to a beta-blocker. Ophthalmology. 1990 Oct;97(10):1245-6. PubMed PMID: 2243671.10: Harper DG, Novack GD, Borrmann LR, Branin MJ. [Dipivefrin: its mechanism of action, clinical efficacy and good tolerance]. Ophtalmologie. 1989 Sep-Dec;3(4):306-7. French. PubMed PMID: 2641142.1

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