82-93-9|Chlorcyclizine free base|1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazine|-范德生物科技公司

Chlorcyclizine free base

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names：
1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazine
CAS号：
82-93-9
MDL Number：
MF(分子式)： C18H21ClN2 MW(分子量)： 300.83
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Chlorcyclizine free base
英文别名	Di-Paralene, Mantadil, Pruresidine, Trihistan, Chlorcyclizine; Chlorcyclizine; Chlorcyclizine free base
CAS号	82-93-9
SMILES	CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1
Inchi	InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
InchiKey	WFNAKBGANONZEQ-UHFFFAOYSA-N
分子式 Formula	C18H21ClN2
分子量 Molecular Weight	300.83
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Chlorcyclizine free base(CAS:82-93-9 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Chlorcyclizine is a first-generation antihistamine of the phenylpiperazine class marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties. It also has been studied as a potential treatment for hepatitis C.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. J Med Chem. 2015 Nov 24. [Epub ahead of print] PubMed PMID: 26599718.

[2]He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Sci Transl Med. 2015 Apr 8;7(282):282ra49. doi: 10.1126/scitranslmed.3010286. PubMed PMID: 25855495.

[3] Enright BP, Gu YZ, Snyder RD, Dugyala RR, Obert LA, Treinen KA, McIntyre BS, Veneziale RW. Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):474-84. doi: 10.1002/bdrb.20261. PubMed PMID: 21058326.

[4] Kvisselgaard N. Chlorpromazine and chlorcyclizine in the prevention of postoperative nausea and vomiting. Acta Anaesth. Scandinav. 1958, 2, 153-162. Acta Anaesthesiol Scand. 2007 Sep;51(8):979-88; discussion 989-90. PubMed PMID: 17697290.

[5] Dastidar SG, Ganguly K, Mahapatra SK, Dutta NK, Mazumdar K, Chakrabarty AN, Motohashi N. Pronounced inhibitory effect of chlorcyclizine (CCZ) in experimental hepatocarcinoma. In Vivo. 2006 Jan-Feb;20(1):97-102. PubMed PMID: 16433035.

6: Kandimalla KK, Donovan MD. Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. PubMed PMID: 15666293.7: Ho Y, Wu H, Wu S, Chen S, Kou H. Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis. Anal Bioanal Chem. 2003 Jul;376(6):859-63. Epub 2003 Jun 26. PubMed PMID: 12830360.8: Brinkley LL, Morris-Wiman J. Effects of chlorcyclizine-induced glycosaminoglycan alterations on patterns of hyaluronate distribution during morphogenesis of the mouse secondary palate. Development. 1987 Aug;100(4):637-40. PubMed PMID: 2894970.9: Brinkley LL, Morris-Wiman J. The effects of chlorcyclizine-induced glycosaminoglycan alterations on palatal mesenchyme-basal lamina relationships in the mouse. Am J Anat. 1986 Jul;176(3):379-89. PubMed PMID: 2874737.10: Heyns CF. Failure of chlorcyclizine to induce cryptorchism in the pig fetus. S Afr Med J. 1985 Aug 17;68(4):212-3. PubMed PMID: 2863877.1

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