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瑞德西韦三磷酸
- names：
GS-443902
- CAS号：
1355149-45-9
MDL Number： - MF(分子式)： C12H16N5O17P3 MW(分子量)： 531.2
- EINECS:NA Reaxys Number:NA
- Pubchem ID:56832906 Brand:BIOFOUNT
瑞德西韦三磷酸（GS-443902,1355149-45-9;Remdesivir triphosphate) 是一种较为有效的病毒RNA依赖的RNA聚合酶 (RdRp) 的抑制剂，对TP RdRp，RSV RdRp 和 HCV RdRp 的 IC50 分别为 5.6 μM，1.1 μM 和 5 μM。GS-443902 属于三磷酸盐衍生产物。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| HCQ000015-1mg | 1mg | ≥95% | ¥ 4500.00 | ¥ 4500.00 | backorder | ¥ 0.00 | ||
| HCQ000015-5mg | 5mg | ≥95% | ¥ 12500.00 | ¥ 12500.00 | backorder | ¥ 0.00 | ||
| HCQ000015-20mg | 20mg | ≥95% | ¥ 22500.00 | ¥ 22500.00 | backorder | ¥ 0.00 | ||
| HCQ000015-100mg | 100mg | ≥95% | ¥ 0.00 | ¥ 0.00 | backorder | ¥ 0.00 |
| 中文别名 | 瑞德西韦三磷酸钠盐衍生物;瑞德西韦三磷酸;1355149-45-9;瑞德西韦衍生物;瑞德西韦三磷酸 |
| 英文别名 | GS-443902;GS 443902;GS443902;1355149-45-9;Remdesivir monophosphate；[[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| CAS号 | 1355149-45-9 |
| SMILES | c1cc(n2c1c(ncn2)N)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N |
| Inchi | InChI=1S/C12H16N5O13P3/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1 |
| InchiKey | DFVPCNAMNAPBCX-LTGWCKQJSA-N |
| 分子式 Formula | C12H16N5O17P3 |
| 分子量 Molecular Weight | 531.2 |
| 闪点 FP | Not available |
| 熔点 Melting point | Not available |
| 沸点 Boiling point | Not available |
| Polarizability极化度 | 39.0±0.5 10-24cm3 |
| 密度 Density | 2.4±0.1 g/cm3 |
| 蒸汽压 Vapor Pressure | Not Avialble |
| 溶解度Solubility | |
| 性状 | 白色粉色粉末 |
| 储藏条件 Storage conditions | -20℃下存储，2-3years；常温下极容易潮解；低温氮气条件下保存。 |
| 产品说明 | 瑞德西韦三磷酸（GS-443902,1355149-45-9,Remdesivir triphosphate) 是一种有效的病毒RNA依赖的 RNA 聚合酶 (RdRp) 的抑制剂，对 TP RdRp，RSV RdRp 和 HCV RdRp 的 IC50 分别为 5.6 μM，1.1 μM 和 5 μM。GS-443902属于三磷酸盐衍生产物。 |
| Introduction | Remdesivir triphosphate（GS-443902,1355149-45-9) IC50: 1.1 μM (RSV RdRp) and 5 μM (HCV RdRp) |
| Application1 | Remdesivir triphosphate is a is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor. It is the active triphosphate metabolite of Remdesivir. |
| Application2 | |
| Application3 |
| 警示图 | |
| 危险性 | |
| 危险性警示 | Not available |
| 安全声明 | H332; H403 |
| 安全防护 | P332+P313; P305+P351+P338 |
| 备注 | 实验过程防止食如、吸入 |
| 【1】. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. |
| 【2】Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. |
| 【3】Gilead Sciences, Foster City, California 94404, USA. |
| 【4】United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center, Frederick, Maryland 21702, USA. |
【5】 The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies B.G. Murphy, M. Perron, E. Murakami, K. Bauer, Y. Park, C. Eckstrand, M. Liepnieks, N.C. Pedersen Vet Microbiol. 2018 Jun; 219: 226–233. Published online 2018 Apr 22. doi: 10.1016/j.vetmic.2018.04.026 PMCID: PMC7117434
【6】 Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease Valeria Avataneo, Amedeo de Nicolò, Jessica Cusato, Miriam Antonucci, Alessandra Manca, Alice Palermiti, Catriona Waitt, Stephen Walimbwa, Mohammed Lamorde, Giovanni di Perri, Antonio D’Avolio J Antimicrob Chemother. 2020 May 3 : dkaa152. Published online 2020 May 3. doi: 10.1093/jac/dkaa152 PMCID: PMC7197584
【7】Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis Niels C Pedersen, Michel Perron, Michael Bannasch, Elizabeth Montgomery, Eisuke Murakami, Molly Liepnieks, Hongwei Liu J Feline Med Surg. 2019 Apr; 21(4): 271–281. Published online 2019 Feb 13. doi: 10.1177/1098612X19825701 PMCID: PMC6435921
【8】 Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses E. Susan Amirian, Julie K. Levy One Health. 2020 Jun; 9: 100128. Published online 2020 Mar 27. doi: 10.1016/j.onehlt.2020.100128 PMCID: PMC7118644
【9】Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison mBio. 2018 Mar-Apr; 9(2): e00221-18. Published online 2018 Mar 6. doi: 10.1128/mBio.00221-18 PMCID: PMC5844999
【10】Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon, Nhung Thi Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard Antiviral Res. 2020 Apr 10 : 104793. doi: 10.1016/j.antiviral.2020.104793 [Epub ahead of print] PMCID: PMC7151495
【11】Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, Matthew D. Hall ACS Cent Sci. 2020 May 4 : acscentsci.0c00489. Published online 2020 May 4. doi: 10.1021/acscentsci.0c00489 PMCID: PMC7202249
【12】Artificial intelligence approach fighting COVID-19 with repurposing drugs Yi-Yu Ke, Tzu-Ting Peng, Teng-Kuang Yeh, Wen-Zheng Huang, Shao-En Chang, Szu-Huei Wu, Hui-Chen Hung, Tsu-An Hsu, Shiow-Ju Lee, Jeng-Shin Song, Wen-Hsing Lin, Tung-Jung Chiang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen Biomed J. 2020 May 15 doi: 10.1016/j.bj.2020.05.001 [Epub ahead of print] PMCID: PMC7227517
【6】 Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease Valeria Avataneo, Amedeo de Nicolò, Jessica Cusato, Miriam Antonucci, Alessandra Manca, Alice Palermiti, Catriona Waitt, Stephen Walimbwa, Mohammed Lamorde, Giovanni di Perri, Antonio D’Avolio J Antimicrob Chemother. 2020 May 3 : dkaa152. Published online 2020 May 3. doi: 10.1093/jac/dkaa152 PMCID: PMC7197584
【7】Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis Niels C Pedersen, Michel Perron, Michael Bannasch, Elizabeth Montgomery, Eisuke Murakami, Molly Liepnieks, Hongwei Liu J Feline Med Surg. 2019 Apr; 21(4): 271–281. Published online 2019 Feb 13. doi: 10.1177/1098612X19825701 PMCID: PMC6435921
【8】 Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses E. Susan Amirian, Julie K. Levy One Health. 2020 Jun; 9: 100128. Published online 2020 Mar 27. doi: 10.1016/j.onehlt.2020.100128 PMCID: PMC7118644
【9】Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison mBio. 2018 Mar-Apr; 9(2): e00221-18. Published online 2018 Mar 6. doi: 10.1128/mBio.00221-18 PMCID: PMC5844999
【10】Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon, Nhung Thi Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard Antiviral Res. 2020 Apr 10 : 104793. doi: 10.1016/j.antiviral.2020.104793 [Epub ahead of print] PMCID: PMC7151495
【11】Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, Matthew D. Hall ACS Cent Sci. 2020 May 4 : acscentsci.0c00489. Published online 2020 May 4. doi: 10.1021/acscentsci.0c00489 PMCID: PMC7202249
【12】Artificial intelligence approach fighting COVID-19 with repurposing drugs Yi-Yu Ke, Tzu-Ting Peng, Teng-Kuang Yeh, Wen-Zheng Huang, Shao-En Chang, Szu-Huei Wu, Hui-Chen Hung, Tsu-An Hsu, Shiow-Ju Lee, Jeng-Shin Song, Wen-Hsing Lin, Tung-Jung Chiang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen Biomed J. 2020 May 15 doi: 10.1016/j.bj.2020.05.001 [Epub ahead of print] PMCID: PMC7227517
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