13412-64-1|双氯西林钠|Dicloxacillin Sodium hydrate|MFCD00056865-范德生物科技公司

双氯西林钠

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names：
Dicloxacillin Sodium hydrate
CAS号：
13412-64-1
MDL Number： MFCD00056865
MF(分子式)： C19H18Cl2N3NaO6S MW(分子量)： 510.32
EINECS:206-444-3 Reaxys Number:
Pubchem ID:23675786 Brand:BIOFOUNT

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)是双氯西林的钠盐形式，双氯西林钠是一种广谱，半合成的β-内酰胺，具有抗细菌和β-内酰胺酶的活性。双氯西林钠与位于细菌细胞壁内膜上的青霉素结合蛋白（PBP）结合。双氯西林钠还能抑制肽聚糖（细菌细胞壁的关键成分）的交联。这导致细菌细胞壁合成的抑制，并最终引起细胞裂解。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000227-50mg	50mg	98.94%	¥ 487.00	¥ 487.00		1-3days	- +	¥ 0.00

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中文别名	双氯西林钠(13412-64-1);全氟丁基磺酸锂;双氯青霉素钠盐水合物;双氯西林钠一水合物;BRL1702; BRL 1702；BRL-1702；P 1011；P-1011；P1011; 3-（2,6-二氯苯基）-5-甲基-4-异恶唑基青霉素;双氯西林钠水合物VETRAN;双氯西林钠EPD（CRM标准）;双氯西林USP（CRM标准）;双氯西林钠（WHO（标准）） -Thia-1-azabicyclo3.2.0heptane-2-carbox；
英文别名	Dicloxacillin Sodium hydrate(13412-64-1);Dicloxacillin sodium salt monohydrate;BRL1702; BRL 1702; BRL-1702; P 1011; P-1011; P1011; 3-(2,6-DICHLOROPHENYL)-5-METHYL-4-ISOXAZOLYL PENICILLIN;DICLOXACILLIN SODIUM SALT HYDRATE VETRAN;DICLOXACILLIN SODIUM EPD(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM WHO(CRM STANDARD);4-Thia-1-azabicyclo3.2.0heptane-2-carbox;
CAS号	13412-64-1
SMILES	[O-]C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O)=O.[Na+].O
Inchi	InChI=1S/C19H17Cl2N3O5S.Na/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);/q;+1/p-1/t13-,14+,17-;/m1./s1
InchiKey	GXOMMGAFBINOJY-SLINCCQESA-M
分子式 Formula	C19H18Cl2N3NaO6S
分子量 Molecular Weight	510.32
闪点 FP	372.5oC
熔点 Melting point	222-225°C
沸点 Boiling point	760mmHg时为692.4°C
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility	生物体外In Vitro:H2O : 25 mg/mL(48.99 mM;Need ultrasonic)
性状	白色至类白色结晶性粉末,Power
储藏条件 Storage conditions	-20°C 3 years，4°C 2 years ，In solvent -80°C 6 months ， -20°C 1 month

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)毒理性质：

生物	测试类型	路线	剂量	影响	参考
man	TDLo	oral	71 mg/kg/5D-I (71 mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN; GASTROINTESTINAL: OTHER CHANGES; LIVER: JAUNDICE, CHOLESTATIC	Journal of Clinical Gastroenterology., 8(77), 1986
rat	LD50	oral	3579 mg/kg (3579 mg/kg)		Toxicology and Applied Pharmacology., 18(185), 1971 [PMID:5542824]
rat	LD50	intraperitoneal	630 mg/kg (630 mg/kg)		Arzneimittel-Forschung. Drug Research., 15(322), 1965 [PMID:5174841]
rat	LD50	intravenous	520 mg/kg (520 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	oral	4560 mg/kg (4560 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	intraperitoneal	1 gm/kg (1000 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
dog	LD50	oral	>3 gm/kg (3000 mg/kg)		Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
rabbit	LD50	oral	>5 gm/kg (5000 mg/kg)		Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
rabbit	LD50	intravenous	600 mg/kg (600 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	subcutaneous	1100 mg/kg (1100 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	intravenous	875 mg/kg (875 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags；双氯西林钠试剂,双氯西林钠杂质,双氯西林钠合成,双氯西林钠溶解度,双氯西林钠密度,双氯西林钠旋光度,双氯西林钠闪点,双氯西林钠熔点,双氯西林钠结构式,双氯西林钠购买,

产品说明	双氯西林钠(13412-64-1,Dicloxacillin sodium salt monohydrate)是青霉素类的一种窄谱β-内酰胺抗生素,用于治疗易感的革兰氏阳性细菌引起的感染
Introduction	双氯西林钠(13412-64-1,Dicloxacillin sodium salt monohydrate)is a narrowpectrum βactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gramositive bacteria,
Application1	双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)active against betaactamaseroducing organisms such as Staphylococcus aureus.
Application2	双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)对革兰氏阳性细菌等产生的β-内酰胺酶的生物（如金黄色葡萄球菌）具有活性。
Application3

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)药理学：

1、双氯西林钠(β-内酰胺化合物双氯西林的一水合钠盐)形式可用作抗生素，尤其是针对革兰氏阳性细菌的抗生素，在生物学研究中也具有重要意义。

2、Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素类的窄谱β内酰胺抗生素, 可用于革兰氏阳性菌感染的研究, 有效对抗β-内酰胺酶产生的微生物如金黄色葡萄球菌。

3、双氯西林钠是双氯西林的钠盐形式，它是一种广谱，半合成的β-内酰胺，具有抗细菌和β-内酰胺酶的活性。双氯西林钠与位于细菌细胞壁内膜上的青霉素结合蛋白（PBP）结合。它还能抑制肽聚糖（细菌细胞壁的关键成分）的交联。这导致细菌细胞壁合成的抑制，并最终引起细胞裂解。

4、双氯西林钠是抗菌剂，双氯西林钠可以抑制细菌生长或繁殖的物质。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)危害标识：

象形图


信号	Danger
GHS危险说明	Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H315 (91.3%): Causes skin irritation [Warning Skin corrosion/irritation]
	H317 (10.87%): May cause an allergic skin reaction [Warning Sensitization, Skin]
	H319 (91.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
	H334 (97.83%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
	H335 (91.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Jusko WJ, et al. Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis. Pediatrics. 1975 Dec;56(6):1038-44.

Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin

Second-derivative spectrophotometric assay of mixtures of dicloxacillin sodium and ampicillin sodium in pharmaceuticals PMID 3244108; Journal of pharmaceutical sciences 1988 Dec; 77(12):1042-6 Name ma

Bacteriology of acute otitis media in Japanese children PMID 6336890; American journal of diseases of children (1960) 1983 Feb; 137(2):152-4 Name matches: ampicillin sodium dicloxacillin sodium

Soft-tissue infections of ampicillin-resistant Haemophilus influenzae type b. The use of ampicillin and nafcillin in their treatment PMID 6972160; American journal of diseases of children (1960) 1981

双氯西林钠(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)参考文献：

1.Selective spectrophotometric determination of phenolic beta-lactam antibiotics.
Salem H1, Saleh GA. J Pharm Biomed Anal. 2002 Jun 15;28(6):1205-13.

Two simple and selective spectrophotometric methods were developed for the quantitative determination of cefoperazone sodium, cefadroxil monohydrate, cefprozil anhydrous and amoxicillin trihydrate in pure forms as well as in their pharmaceutical formulations. The methods are based on the selective oxidation of these drugs with either Ce (IV) or Fe (III) in acid medium to give an intense yellow coloured product (lambda(max)=397 nm). The reaction conditions were studied and optimized. Beer's plots were obeyed in a general concentration range of 5-30 microg ml(-1) with correlation coefficients not less than 0.9979 for the four drugs with the two reagents. The methods are successfully applied to the analysis of pharmaceutical formulations containing amoxicillin, either alone or in combination with potassium clavulanate, flucloxacillin or dicloxacillin. They were also applied to the analysis of the other three studied drugs in vials, capsules, tablets and suspensions with good recovery; percent ranged from 99.

2.Bacteriology of acute otitis media in Japanese children.
Fujita K, Iseki K, Yoshioka H, Sasaki T, Ando T, Nakamura M. Am J Dis Child. 1983 Feb;137(2):152-4.

Bacteriologic investigations were performed on 100 children with acute otitis media by culturing the fluid from a myringotomy site. Patients ranged in age from 7 months to 14 years, and 91 were younger than 6 years old. Bacterial isolates were yielded from cultures in 83 cases, and mixtures of two or three organisms were obtained from 15 patients. Among the total of 100 isolates, the most predominant organism was Streptococcus pneumoniae (28), followed by Hemophilus influenzae (26), Staphylococcus aureus (19), and Streptococcus pyogenes (six). Minimal inhibitory concentrations (MICs) of ampicillin sodium against S pneumoniae and H influenzae were 0.016 to 0.032 and 0.25 to 0.5 mg/L, respectively. None of the strains of H influenzae were resistant to ampicillin. The MICs of dicloxacillin sodium, cephalexin monohydrate, cefaclor, and erythromycin to H influenzae were 8 to 32, 8 to 16, 2 to 8, and 2 to 8 mg/L, respectively. The preferred drug for acute otitis media would be ampicillin in Japan, but we have to consider antistaphylococcal antibiotics for the patients who do not respond to 48 hours of treatment.

3.Sodium dicloxacillin monohydrate: an anti-staphylococcus antibiotic.
Keefe TJ, Christie GJ. Acta Chir Plast. 1973;15(1):904 passim.

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