90274-24-1|盐酸莱克多巴胺|Ractopamine hydrochloride|MFCD07781271-范德生物科技公司

盐酸莱克多巴胺

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names：
Ractopamine hydrochloride
CAS号：
90274-24-1
MDL Number： MFCD07781271
MF(分子式)： C18H23NO3 MW(分子量)： 301.38
EINECS:415-170-5 Reaxys Number:
Pubchem ID:14010333 Brand:BIOFOUNT

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)是一种具有β-肾上腺素能激动剂特性的苯乙醇胺，盐酸莱克多巴胺具有增加肌肉质量和减少啮齿动物和牲畜体内脂肪的作用。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK18450-100mg	100mg	>98%	¥ 3080.00	¥ 3080.00		2 Weeks	- +	¥ 0.00

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中文别名	盐酸莱克多巴胺(90274-24-1);4-[3-[2-羟基-2-(4-羟基苯基)-乙基]氨基丁基]苯酚盐酸盐;莱克多巴胺氯化氢;莱克多巴胺氯化氢溶液;
英文别名	Ractopamine hydrochloride(90274-24-1);4-(1-hydroxy-2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)phenol;Ractopamine HCl; Ractopamine Hydrochloride;4-Hydroxy-α-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]phenol hydrochloride; EL 737; LY 031537; EL-737; LY-031537; EL737; LY O31537; Optaflexx; Paylean; Topmax 9;
CAS号	90274-24-1
Inchi	InChI=1S/C18H23NO3/c1-13(2-3-14-4-8-16(20)9-5-14)19-12-18(22)15-6-10-17(21)11-7-15/h4-11,13,18-22H,2-3,12H2,1H3
InchiKey	YJQZYXCXBBCEAQ-UHFFFAOYSA-N
分子式 Formula	C18H23NO3
分子量 Molecular Weight	301.38
溶解度Solubility
性状	白色至近乎于白色结晶粉末
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	盐酸莱克多巴胺(90274-24-1,EL-737)是一种具有β-肾上腺素能激动剂特性的苯乙醇胺,盐酸莱克多巴胺溶解度,盐酸莱克多巴胺MSDS详见主页.
Introduction	盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)is a beta-Adrenergic agonist. It acts by being a full agonist at the TAAR1.
Application1
Application2
Application3

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)药理学：

1、盐酸莱克多巴胺是一种具有β-肾上腺素能激动剂特性的苯乙醇胺，具有增加肌肉质量和减少啮齿动物和牲畜体内脂肪的作用。

2、盐酸莱克多巴胺是痕量胺1（TA1）受体激动剂；盐酸莱克多巴胺可以增加共表达hCFTR和小鼠TA1受体的卵母细胞中的氯离子传导。

3、盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)是肾上腺素β激动剂，盐酸莱克多巴胺是选择性结合并激活β-肾上腺素受体的药物。

警示图
危险性	Warning
危险性警示	No data available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)危害标识：

象形图
信号	Warning
GHS危险说明	H302: Harmful if swallowed [Warning Acute toxicity, oral]
	H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
	H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
防范说明代码	P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P330, P333+P313, P363, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Mendoza SM, Boyd RD, Zier-Rush CE, Ferket PR, Haydon KD, van Heugten E. Effect of natural betaine and ractopamine HCl on whole-body and carcass growth in pigs housed under high ambient temperatures. J Anim Sci. 2017 Jul;95(7):3047-3056. doi: 10.2527/jas.2017.1622. PubMed PMID: 28727090.

Cadaret CN, Beede KA, Riley HE, Yates DT. Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cytokine. 2017 Aug;9

6:107-113. doi: 10.1016/j.cyto.2017.03.014. Epub 2017 Apr 5. PubMed PMID: 28390265; PubMed Central PMCID: PMC5483180.

Ebarb SM, Phelps KJ, Drouillard JS, Maddock-Carlin KR, Vaughn MA, Burnett DD, Noel JA, Van Bibber-Krueger CL, Paulk CB, Grieger DM, Gonzalez JM. Effects of anabolic implants and ractopamine-HCl on muscle fiber morphometrics, collagen solubility, and tenderness of beef longissimus lumborum steaks. J Anim Sci. 2017 Mar;95(3):1219-1231. doi: 10.2527/jas.2016.1263. PubMed PMID: 28380530.

Smith DJ, Shelver WL, Marx A. Detection of residues in urine and tissues of sheep treated with trace levels of dietary ractopamine HCl. J Anim Sci. 2016 Dec;94(12):5423-5433. doi: 10.2527/jas.2016-0899. PubMed PMID: 28046138.

盐酸莱克多巴胺(Ractopamine hydrochloride,90274-24-1,EL-737,LY-031537)参考文献：

1.The effects of a step-up ractopamine feeding program on growth performance and low-sodium ham characteristics of purebred Berkshire pigs.
Bohrer BM;Kyle JM;Little KL;Zerby HN;Boler DD J Anim Sci. 2013 Nov;91(11):5535-43. doi: 10.2527/jas.2013-6854. Epub 2013 Sep 17.

Objectives were to test the effect of a low-sodium curing solution on processing characteristics of hams from purebred Berkshire pigs that were fed a step-up ractopamine HCl (RAC) feeding program or a negative control diet. Sixty pairs (n=120) of hams were selected from two blocks of purebred Berkshire pigs (n=200) that were fed either a control diet or 7.4 mg of ractopamine/kg of diet for 14 d followed by 10.0 mg of ractopamine/kg of diet for the last 14 d before slaughter. Three-piece, section-formed hams were cured with a standard (1.98% NaCl; REG) curing solution or a low-sodium with KCl replacement (0.67% NaCl and 1.29% KCl; LOW) curing solution. Pigs fed RAC had 3.18% greater BW, 11.90% greater ADG, and 10.34% greater G:F compared with control pigs. No differences (P≥0.07) were detected for the effect of diet, curing solution, or the interaction between diet and curing solution for ham weights, pump uptake, or cook yield [(cooked weight/green weight) 100]. Break strength (an indication of protein interaction and bind strength; 5.97 vs. 6.99 kg) and protein fat-free values (24.58 vs. 25.98%) were less (P≤0.05) in hams cured with LOW curing solution compared with hams cured with REG curing solution.

2.Effects of immunocastration and a β-adrenergic agonist on retail cuts of feedlot finished Nellore cattle.
Brigida DJ;Antonelo DS;Mazon MR;Nubiato KEZ;Gómez JFM;Netto AS;Leme PR;Cônsolo NRB;Pesce DMC;Silva SL Animal. 2018 Aug;12(8):1690-1695. doi: 10.1017/S1751731117003317. Epub 2017 Dec 19.

Immunocastration (ImC) has been proposed as an animal welfare-friendly alternative to reduce sexual and aggressive behavior and to increase carcass fat deposition with positive effects on meat quality. The β-adrenergic agonists (β-AA) are known as repartitioning agents that acts increasing lean tissue deposition. The combined use of these technologies can positively affect meat quality and increase retail cuts yield. Thus, this research was conducted to evaluate the combined effects of ImC and β-AA (zilpaterol hydrochloride (ZH) and ractopamine hydrochloride (RH)) on retail cuts, bones, and fat trim of feedlot finished Bos indicus (Nellore) cattle. No interaction was observed between sexual condition and diet for any trait. The ImC decreased cold carcass, hindquarter (HQ), forequarter (FQ) and combined brisket, short ribs and flank (BSF) weights. The ImC also showed smaller weights of retail cuts and bones on the HQ and on the FQ than non-castrated (NoC). Fat trim weights did not differ from ImC and NoC. The most of subprimal cuts were heavier in NoC than in ImC. Feeding β-AA did not affect cold carcass weight; however, animals fed ZH had higher weights of HQ and retail cuts in HQ when compared with RH and control (CO) group, with no differences between RH and CO for both traits.

3.Lipid metabolism related gene-expression profiling in liver, skeletal muscle and adipose tissue in crossbred Duroc and Pietrain Pigs.
Reiter SS;Halsey CH;Stronach BM;Bartosh JL;Owsley WF;Bergen WG Comp Biochem Physiol Part D Genomics Proteomics. 2007 Sep;2(3):200-6. doi: 10.1016/j.cbd.2007.04.008. Epub 2007 May 13.

Body-weight differences in animals may be ascribed to genetic and environmental factors. Here we utilized two divergent porcine genotypes, the highly muscled, leaner PietrianxYorkshire pigs and less muscled, fatter DurocxYorkshire growing pigs (75-110 kg), to examine the role of genetic background on expression of genes associated with anabolic (Fatty acid synthase, FAS; glucose transporter 4, GLUT-4; stearoyl CoA desaturase, SCD; Sterol regulatory binding protein-1, SREBP-1; leptin) and catabolic lipid metabolism (Carnitine palmitoyltransferase-1B, CPT-1B; acyl-CoA dehydrogenase, ACDH) in adipose tissue (AT), liver (L) and skeletal muscle (SKM). Pietrain pigs had lower mRNA abundance for FAS, SREBP-1, SCD and leptin in AT and L, but higher mRNA abundance for L ACDH and SKM ACDH and CPT-1B than Durocs. Duroc pigs exhibited higher expression of FAS, SREBP-1, SCD, leptin in AT and FAS in L and lower expression of ACDH and CPT-1B in L SKM. GLUT-4 expression did not differ in SKM between the two genotypes. Feeding of a beta adrenergic agonist (Paylean) for 52 days lowered expression of lipid anabolic and enhanced lipid catabolic genes expressions similarly in both genotypes. Overall, the lipid metabolism genes differential expression patterns documented here showed that in Pietrain pigs mRNA abundances of synthesis genes were lower and of catabolic genes were higher than in Duroc pigs.

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